Nelson Vergel
Founder, ExcelMale.com
Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism
Caronia, Lisa M ; Dwyer, Andrew A ; Hayden, Douglas ; Amati, Francesca ; Pitteloud, Nelly ; Hayes, Frances J
Clinical endocrinology (Oxford), 2013, Vol.78 (2), p.291-296
Design
Cross‐sectional study.
Patients and Methods
74 men (19–74 years, mean 51·4 ± 1·4 years) underwent a standard 75‐g oral glucose tolerance test with blood sampling at 0, 30, 60, 90 and 120 min. Fasting serum glucose, insulin, total T (and calculated free T ), LH , SHBG , leptin and cortisol were measured.
Results
57% of the men had normal GT , 30% had impaired GT and 13% had newly diagnosed type 2 diabetes. Glucose ingestion was associated with a 25% decrease in mean T levels (delta = −4·2 ± 0·3 nm , P < 0·0001). T levels remained suppressed at 120 min compared with baseline (13·7 ± 0·6 vs 16·5 ± 0·7 nm , P < 0·0001) and did not differ across GT or BMI . Of the 66 men with normal T levels at baseline, 10 (15%) had levels that decreased to the hypogonadal range (<9·7 nm ) at one or more time points. SHBG , LH and cortisol levels were unchanged. Leptin levels decreased from baseline at all time points (P < 0·0001).
Conclusions
Glucose ingestion induces a significant reduction in total and free T levels in men, which is similar across the spectrum of glucose tolerance. This decrease in T appears to be because of a direct testicular defect, but the absence of compensatory changes in LH suggests an additional central component. Men found to have low nonfasting T levels should be re‐evaluated in the fasting state.
Sugar-sweetened beverage intake and serum testosterone levels in adult males 20–39 years old in the United States
Chen, Liang ; Xie, Yu-Mei ; Pei, Jian-Hao ; Kuang, Jian ; Chen, Hong-Mei ; Chen, Zhong ; Li, Zhong-Wen ; Fu, Xiao-Ying ; Wang, Long ; Lai, Shui-Qing ; Zhang, Shu-Ting ; Chen, Zhi-Jiang ; Lin, Jin-xin
Reproductive biology and endocrinology, 2018, Vol.16 (1), p.61-7
This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old. All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m had a higher risk of having a low testosterone level than those with BMI < 25 kg/m (aOR = 3.68, p = 0.044). SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States.
Caronia, Lisa M ; Dwyer, Andrew A ; Hayden, Douglas ; Amati, Francesca ; Pitteloud, Nelly ; Hayes, Frances J
Clinical endocrinology (Oxford), 2013, Vol.78 (2), p.291-296
Design
Cross‐sectional study.
Patients and Methods
74 men (19–74 years, mean 51·4 ± 1·4 years) underwent a standard 75‐g oral glucose tolerance test with blood sampling at 0, 30, 60, 90 and 120 min. Fasting serum glucose, insulin, total T (and calculated free T ), LH , SHBG , leptin and cortisol were measured.
Results
57% of the men had normal GT , 30% had impaired GT and 13% had newly diagnosed type 2 diabetes. Glucose ingestion was associated with a 25% decrease in mean T levels (delta = −4·2 ± 0·3 nm , P < 0·0001). T levels remained suppressed at 120 min compared with baseline (13·7 ± 0·6 vs 16·5 ± 0·7 nm , P < 0·0001) and did not differ across GT or BMI . Of the 66 men with normal T levels at baseline, 10 (15%) had levels that decreased to the hypogonadal range (<9·7 nm ) at one or more time points. SHBG , LH and cortisol levels were unchanged. Leptin levels decreased from baseline at all time points (P < 0·0001).
Conclusions
Glucose ingestion induces a significant reduction in total and free T levels in men, which is similar across the spectrum of glucose tolerance. This decrease in T appears to be because of a direct testicular defect, but the absence of compensatory changes in LH suggests an additional central component. Men found to have low nonfasting T levels should be re‐evaluated in the fasting state.
Sugar-sweetened beverage intake and serum testosterone levels in adult males 20–39 years old in the United States
Chen, Liang ; Xie, Yu-Mei ; Pei, Jian-Hao ; Kuang, Jian ; Chen, Hong-Mei ; Chen, Zhong ; Li, Zhong-Wen ; Fu, Xiao-Ying ; Wang, Long ; Lai, Shui-Qing ; Zhang, Shu-Ting ; Chen, Zhi-Jiang ; Lin, Jin-xin
Reproductive biology and endocrinology, 2018, Vol.16 (1), p.61-7
This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old. All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m had a higher risk of having a low testosterone level than those with BMI < 25 kg/m (aOR = 3.68, p = 0.044). SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States.
