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Fortunate

Active Member
Since @Zibernet has gone radio silent, does anyone else out there want to comment? I am curious why abdominal application would work better for him? I also want to know why he switched (I think he was doing high-dose scrotal twice a day). Was it too much? Does abdominal work better because he is actually absorbing less and he is less likely to experience side effects from supraphysiologic testosterone and/DHT?

The package inserts on most of the commercial forms of creams specifically say not to apply to the abdomen. I am not sure why, but my guess is that absorption may be reduced compared to other sites (at least one study showed this)?

Can anyone who has or is using cream weigh in?
 
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JA Battle

Active Member
The rationale behind abdominal application is to try to target tissue types that are known for higher aromatase activity. He has lower e2 numbers. Absorption may be a factor too but not necessarily significant.
 

Fortunate

Active Member
The rationale behind abdominal application is to try to target tissue types that are known for higher aromatase activity. He has lower e2 numbers. Absorption may be a factor too but not necessarily significant.
Thanks for your response!

Do you happen to know of a study that references aromatase activity based on location? I will search for it if you don't happen to know.
 

JA Battle

Active Member
Thanks for your response!

Do you happen to know of a study that references aromatase activity based on location? I will search for it if you don't happen to know.
Adipose tissue. Most people have more adipose tissue in the belly area. Aromatase is expressed moreso in adipose tissue vs most other tissues.
 

Fortunate

Active Member
This study would suggest upper body fat has a lower estrogen to DHT ratios compared to lower body fat.

This study suggests Testim is absorbed best in the arms; chest or abdomen is similar or better absorbed than legs.

Would love to hear more chime in with either anecdotes or references to useful studies.

So far, in my experience, scrotal application makes me feel very anxious. Moderate dose (75mg) on the arms also made me anxious. With either application, I also feel a "crashy" feeling between 2 and 4PM (8-10 hours after application). This study would suggest T levels are dropping around this time. Am I feeling that? Am I feeling DHT spiking?

I am willing to try (aka torture myself) another site (perhaps 50mg on abdomen) and report back.
 

Graham

Member
Scrotum application could of been sending his levels too high. Elsewhere on the body might of brought T levels to more normal levels. I feel calmer on cream as opposed to injections
 
Last edited:

Zibernet

Active Member
I have a few follow-up questions: what dose are you using? What do you think accounts for the improved experience? Have you tried a similar dose on the shoulders? If so, how is your current protocol better than applying to the shoulders?

Never tried any other area than scrotum and abdomen.
I'm applying 3 clicks morning and 3 clicks pm (300mg total in Pentravan cream).
I would venture to guess that higher e2 conversion and lower DHT conversion is what makes me feel good and less anxious.
You may be right I'm also most likely absorbing overall less testosterone, although I have no bloods yet to check that.

One more idea that is purely speculative: I imagine that all this belly fat serves as a bigger reservoir for the testosterone to be slowly released, whereas the scrotum skin is so thin that it doesn't hold any of it, test is straight shuttled to the bloodstream.
So maybe there is a more consistent and gradual release with belly application.
 

Fortunate

Active Member
Never tried any other area than scrotum and abdomen.
I'm applying 3 clicks morning and 3 clicks pm (300mg total in Pentravan cream).
I would venture to guess that higher e2 conversion and lower DHT conversion is what makes me feel good and less anxious.
You may be right I'm also most likely absorbing overall less testosterone, although I have no bloods yet to check that.

One more idea that is purely speculative: I imagine that all this belly fat serves as a bigger reservoir for the testosterone to be slowly released, whereas the scrotum skin is so thin that it doesn't hold any of it, test is straight shuttled to the bloodstream.
So maybe there is a more consistent and gradual release with belly application.
Makes sense. Do you have a lot of belly fat? Are you applying on the front part of the abdomen or love handle area, where there tends to be more fat?

Thanks for your feedback.
 

Zibernet

Active Member
Makes sense. Do you have a lot of belly fat? Are you applying on the front part of the abdomen or love handle area, where there tends to be more fat?

Thanks for your feedback.

I'm very lean with a 6 pack showing.
Still there's A LOT more aromatase in my flat belly than on my scrotum.
In between those two areas.
 
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