Probiotics Improve Sperm Count and Function



Decreased sperm motility is one of the main causes of male infertility. The aim of this study was to evaluate the effects of probiotic supplementation on semen quality, seminal oxidative stress biomarkers, inflammatory factors, and reproductive hormones. In this randomized, double-blind controlled clinical trial, 52 men with idiopathic oligoasthenoteratozoospermia attending a urology clinic, were randomly assigned to either an intervention or placebo (n ¼ 26) group. This investigation was registered by the identification code of IRCT20141025019669N7 in the clinical trial registry of Iran. The Intervention group took 500 mg of Probiotics daily and the placebo group took a daily placebo for 10 weeks. Semen parameters, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at baseline and at the end of the study. After the intervention, ejaculate volume, number, concentration, and the percentage of motile sperm, the total antioxidant capacity of plasma significantly increased and the concentration of plasma malondialdehyde and inflammatory markers significantly decreased in the intervention group. Probiotic supplementation in infertile men leads to a significant increase in sperm concentration and motility and a significant reduction in oxidative stress and inflammatory markers. Therefore, oral intake of probiotics has the potential to be one of the ways to deal with oxidative damage of sperm.

In conclusion, the results of this study indicated that 10 weeks of treatment with probiotics can improve sperm function. After 10 weeks of treatment in oligoasthenoteratozoospermia men, mean count, concentration, and motility increased significantly compared with the placebo group. Based on our findings, medical therapy of oligoasthenoteratozoospermia with oral antioxidants can improve the quality of semen parameters.



Table 2. Within- and between-group comparison of sperm quality parameters in baseline and after intervention in two groups
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Table 3. Within and between-group comparisons of the oxidative stress biomarkers and inflammatory factors from baseline to endpoint in two groups.
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Table 4. Within and between-group comparisons of sex hormones biomarkers from baseline to endpoint in two groups
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Nelson Vergel