Efficacy of coenzyme Q10 on semen parameters

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Vince

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Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. - PubMed - NCBI
PURPOSE:

We determined the efficacy of coenzyme Q10 supplementation on semen parameters, sperm function and reproductive hormone profiles in infertile men.

MATERIALS AND METHODS:A total of 212 infertile men with idiopathic oligoasthenoteratospermia were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase. Two semen analyses, acrosome reaction test, immunobead test for antisperm antibody, and determination of resting levels of luteinizing hormone, follicle-stimulating hormone, prolactin, testosterone and inhibin B were done in all participants. Blood and seminal plasma total coenzyme Q10 was also assessed.

RESULTS:Significant improvement in sperm density and motility was evident with coenzyme Q10 therapy (each p = 0.01). Using the Kruger classification sperm morphology evaluation revealed an increase in the percent of normal forms in the coenzyme Q10 group (p = 0.07). A positive correlation was found between treatment duration with coenzyme Q10 and sperm count (r = 0.46, p = 0.03) as well as with sperm motility (r = 0.45, p = 0.04) and sperm morphology (r = 0.34, p = 0.04). The coenzyme Q10 group had a significant decrease in serum follicle-stimulating hormone and luteinizing hormone at the 26-week treatment phase (each p = 0.03). By the end of the treatment phase the mean +/- SD acrosome reaction had increased from 14% +/- 8% and 15% +/- 8% to 31% +/- 11% and 16% +/- 10% in the coenzyme Q10 and placebo groups, respectively (p = 0.01).

CONCLUSIONS: Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters. However, further studies are needed to draw a final conclusion and evaluate the effect of coenzyme Q10 supplementation on the pregnancy rate.
 
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Defy Medical TRT clinic doctor

Vince

Super Moderator
Coenzyme Q10 is a vitamin-like substance found in body cells, especially in the heart, kidney, liver, and pancreas, that may promote health and fight some diseases. Scientists believe CoQ10 functions as an antioxidant that blocks actions that can damage cells. New studies have found that supplements of CoQ10 can help improve sperm movement in infertile men. Decreased sperm motility is one of the leading causes of male infertility.
https://www.fertilityauthority.com/...rtility/coenzyme-q10-coq10-and-male-fertility
 
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