Metformin Decreases Aerobic Capacity, Muscle Mass and Testosterone

Rock H. Johnson

Active Member
I have been on 2x1000mg a day but I lost my endurance(Kun Khmer/Muay Thai training) and workout capacity/volume. I had no common sides from it, no diarrea etc, but felt physically limited.
A strange feeling of being limited by the amount of energy the body had stored or could generate on the mitochondrial level. More like a cellular exhaustion. Stopped taking it after 5 months and have not experienced that any longer. I do still like the promise of Metformin and will use it again when I will slow down...... (ends with a 2-min cameo by @nelsonvergel)

 

Vince

Super Moderator
I've been on metformin for many years now and I really like the drug. But after reading articles like this one. I wonder how I would feel if I stop taking it. My ac-1 and fasting glucose has been in a pretty good range for a long time (I eat low carb). I also have been on a low-carb diet, which really helped to be controlled my insulin resistance.
 

Nelson Vergel

Founder, ExcelMale.com

Robotics

Active Member
I am guessing low dose berberine has similar negative effects? is there some sort of balance on dosage where the effects are minimal?
 

n2turbo2

Member
I was thinking of starting Metformin, I stumbled on this on the web. Metformin medication may help treat erectile dysfunction. New research suggests that the widely used type 2 diabetes drug metformin could double as a treatment for men with erectionproblems. .. Is this true?
 

Nelson Vergel

Founder, ExcelMale.com
To study the effect of metformin on androgens in normal men. A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.


effect of metformin on men hormones testosterone.jpg
 

DragonBits

Well-Known Member
To study the effect of metformin on androgens in normal men. A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.


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Here is the rub for most of "us" here.

Does metformin lower the level of testosterone in those of us that inject and aren't producing testosterone naturally? (I would guess not, but LH in before and after Met didn't change as much as total T.) Is our SHBG affected?
 

sokaiya

Active Member
i've never had that issue and i take 750mg ER at night. I easily gain muscle and I'm a competitive boxer. Guys, these studies are done on regular couch potatoes for the most part they are not done on hyper-muscular individuals who are on mod to high dosage of testosterone and anything else. Until they control for those variables i'll take these studies with a grain of salt.
 
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