wondering

Active Member
Libido and ED as bad as they have ever been. Tried Prog at night per Dr. Saya's recommendation and no help at all. In the last month, I have weaned off HC after being on it for years and I feel a bit calmer without it, but the sexual dept is as stated. 25 years of this. Close to throwing in the towel, but always find something on the internet to pull you back. I have wondered about Histamine for awhile now and the whole Methylation thing is a bit confusing as many symptoms seem like they could belong to either side.

Nevertheless, even though I have seasonal allergies, I wonder if I am low Histamine. From this link in bottom right... Histamine - an overview | ScienceDirect Topics

"In addition, histamine also plays a role in sexual dysfunction, and supplementation with folic acid and niacin (used together), as well as L-histidine (an enzyme that metabolizes histamine from histidine) has been shown to be effective in addressing histamine deficiencies. Low levels of histamine have also been shown to correlate with schizophrenia."

So, I ordered some L-Histidine, Niacinamide (already have the Methylfolate) and will try that.
 

wondering

Active Member
Libido and ED as bad as they have ever been. Tried Prog at night per Dr. Saya's recommendation and no help at all. In the last month, I have weaned off HC after being on it for years and I feel a bit calmer without it, but the sexual dept is as stated. 25 years of this. Close to throwing in the towel, but always find something on the internet to pull you back. I have wondered about Histamine for awhile now and the whole Methylation thing is a bit confusing as many symptoms seem like they could belong to either side.

Nevertheless, even though I have seasonal allergies, I wonder if I am low Histamine. From this link in bottom right... Histamine - an overview | ScienceDirect Topics

"In addition, histamine also plays a role in sexual dysfunction, and supplementation with folic acid and niacin (used together), as well as L-histidine (an enzyme that metabolizes histamine from histidine) has been shown to be effective in addressing histamine deficiencies. Low levels of histamine have also been shown to correlate with schizophrenia."

So, I ordered some L-Histidine, Niacinamide (already have the Methylfolate) and will try that.
Then again, I have massive ADHD which would indicate the opposite. So who knows.
 

Gman86

Member
Have u had prolactin levels checked? Dopamine and prolactin have an inverse relationship. So if u do in fact have low dopamine, u would probably have elevated prolactin, which obv has the ability to mess with sexual function.
 

wondering

Active Member
Have u had prolactin levels checked? Dopamine and prolactin have an inverse relationship. So if u do in fact have low dopamine, u would probably have elevated prolactin, which obv has the ability to mess with sexual function.
yes, ranges from ok to low to high. Tried lowering with whatever drug lowers it. No change to libido and felt awful.
 

wondering

Active Member
For those of us with HPA issues, perhaps something to being low histamine. Much is made of histamine intolerance and much much less is written about the reverse. My horrible libido has always been driven to zero by acid-reducers and when younger (early 20s) by antihistamines for hay fever. I'm not sure I'm a believer that just because I have seasonal allergies that my histamine is high, perhaps something else going on with histamine or at the receptor level.
 

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