I agree with you, easternpromise.
So, would it make sense that my trt doc suggests stopping TRT based on having FVL, but, with NO thrombosis event ever occurring?I agree with you, easternpromise.
I can't believe that after 5 years, his assessments remain a one-way ticket to another dead end: staying hypogonadal which is no better option. Also, T reduces Lp(a): Testosterone-induced suppression of lipoprotein(a) in normal men; relation to basal lipoprotein(a) level. - PubMed - NCBIMore from Glueck
J Investig Med. 2018 Apr;66(4):733-738. doi: 10.1136/jim-2017-000637. Epub 2017 Dec 15.
Thromboembolism peaking 3 months after starting testosterone therapy: testosterone-thrombophilia interactions.
Glueck CJ1, Goldenberg N1, Wang P1.
We assessed time of thrombotic events (venous thromboembolism (VTE)) after starting testosterone therapy (TT) in 21 men who sustained 23 VTE. The density of thrombotic events was greatest at 3 months after starting TT, with a rapid decline in events by 10 months. The 21 cases with VTE on TT differed from 110 patient controls with unprovoked VTE, not taking TT (VTE-no TT) for Factor V Leiden heterozygosity (FVL) (33 per cent vs 13 per cent, P=0.037), for high lipoprotein (a) (Lp(a)) (55 per cent vs 17 per cent, P=0.012), and for the lupus anticoagulant (33 per cent vs 4 per cent, P=0.003). These differences between cases and VTE-no TT controls were independent of age and gender. TT can interact with underlying thrombophilia-hypofibrinolysis promoting VTE. We suggest that TT should not be started in subjects with known thrombophilia. Coagulation screening, particularly for the FVL , Lp(a), and the lupus anticoagulant should be considered before starting TT, to identify men at high VTE risk who have an adverse risk/benefit ratio for TT.
pulmonary embolism; testosterone; thromboembolism; thrombophilia; thrombosis
I did not know. Some believe he created an irrational fear that made the FDA add a black box warning on every testosterone product package insert.I do believe the good doc has since retired? If so who took over for him? Last i heard it was his daughter, perhaps?
So i have some questions in regards to that statement and the docI did not know. Some believe he created an irrational fear that made the FDA add a black box warning on every testosterone product package insert.