Can estrogen crash cause desensitization/knock out of the estrogen receptor - lets discuss!

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@Coconutz did you have any erections issues prior to starting exogenous estradiol? I know some guys have reported ED while others just report low libido and feeling like shit. It's a wide spectrum.

From what I've read, it appears estrogen receptors (specifically, ER-alpha receptors) have some governance over the expression of androgen receptors, so without the former, the latter can definitely not work optimally. Potentially this is why guys report not "feeling" testosterone and other androgenics/anabolics when their estro signaling is impaired.
 
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Coconutz

New Member
@Coconutz did you have any erections issues prior to starting exogenous estradiol? I know some guys have reported ED while others just report low libido and feeling like shit. It's a wide spectrum.

From what I've read, it appears estrogen receptors (specifically, ER-alpha receptors) have some governance over the expression of androgen receptors, so without the former, the latter can definitely not work optimally. Potentially this is why guys report not "feeling" testosterone and other androgenics/anabolics when their estro signaling is impaired.
I've always been able to get it up and keep it up, that's why I never really knew what the problem was at first. I'd even have an unhealthy HYPER High uncontrollable libido when I'd crash estrogen. Super anxious, super jealous and just stupid compulsive paranoid thoughts like everyone was out to get me. My erections are much much more full now. Orgasms way more sensitive, balls more full too and hang better. Little sore too. I kinda feel like I'm taking HCG. Now that I look back, I guess my erections have been about 80% compared to now.

I read somewhere about giving schizophrenic men estradiol injections. Kinda makes me wonder if a lot of those issues are low estrogen. Because i sure as shit thought I was losing my mind.
 

Gman86

Member
I've always been able to get it up and keep it up, that's why I never really knew what the problem was at first. I'd even have an unhealthy HYPER High uncontrollable libido when I'd crash estrogen. Super anxious, super jealous and just stupid compulsive paranoid thoughts like everyone was out to get me. My erections are much much more full now. Orgasms way more sensitive, balls more full too and hang better. Little sore too. I kinda feel like I'm taking HCG. Now that I look back, I guess my erections have been about 80% compared to now.

I read somewhere about giving schizophrenic men estradiol injections. Kinda makes me wonder if a lot of those issues are low estrogen. Because i sure as shit thought I was losing my mind.
This is all so interesting. I always thought too high of E2 would cause the penis and scrotum to retract. So it’s interesting that taking exogenous E2 is doing the complete opposite.

Did taking oral E2 increase penile sensitivity, or just improve ur orgasms?

Do u get the oral E2 valerate prescribed? Was it covered by insurance (if prescribed obv)

Why do u think exogenous oral E2 is working for u and raising ur E2 with more test didn’t?

Any long term downsides to using oral E2 over injectable?

Back when u were testing ur E2, would it come back low? Or would it come back normal, yet u would still feel low E2 symptoms?
 
Last edited:

Gman86

Member
For those of u suffering with low E2 symptoms, do u all have low E2 serum levels, or normal E2 levels on labs, but still have low E2 symptoms? Basically indicating issues at the estrogen receptor
 

Lowe2guy

New Member
What dose were you using and where were you applying it?

What was your TRT protocol when using the e2 cream?
Dosing 1mg every night before bed, on my inner arms. My current protocol is 150mg a week split into EOD injections but Im going to move to E5D to hopefully scew the ratio of T to E in favor of E of course without the use of the cream.This cream is seriously working though.My libido is now going up and I now have morning wood again. Never in a million years would I think estrogen would be the missing link. Crazy…
 

Lowe2guy

New Member
For those of u suffering with low E2 symptoms, do u all have low E2 serum levels, or normal E2 levels on labs, but still have low E2 symptoms? Basically indicating issues at the estrogen receptor
I had borderline “high” e2 on bloodwork but all low e2 symptoms although I cant get the sensitive estradiol test in Canada. Im guessing the standard test is grossly overestimating my e2 because it apparently cross reacts with CRP and I have elevated CRP.
 

Bmac

New Member
It's night and day supplementing estrogen. I can't believe I'm saying that lol. Care to share your protocol?

I think a lot of bodybuilders need to be warned not touch aromasin. It worked amazing in my 20s while bodybuilding and blasting a gram plus of test plus whatever else.. but It seems to permanently disable the aromatase enzyme, or close to it for years and years after discontinuation. If notpermanently. I literally took that shit for probably 5-6 years straight, and 12 years total off and on. I'm 40 now.

My sleeps been amazing, and what I thought was eczema that I've had for years is going away. Ive tried posting this on bodybuilding forums, and got completely flamed. Soooo. Fuck em. One day when they are in our shoes they'll understand.
Testosterone cypionate at 100mg a week split into two doses. My first experiment with oral e2 was 1mg daily for 2 months. Had stopped for about 4 months to see if any of my symptoms would return, which they did. I’m now taking .5mg daily and possibly trying a EoD dosing schedule as I’m looking for the lowest but effective dose for me. Just to clarify are you taking 2mg daily or is it 2mg total a week?
 
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