Growth Hormone versus GHRH Peptides- Legalities and other considerations

In this video, Dr Mark Gordon speaks about secretalogs (hormone releasing hormones or peptides) at the 2013 Age Management Medicine Conference in Las Vegas.




GH and Peptides.webp


This lecture by Dr. Mark L. Gordon discusses the use of secretagogues in Age Management Interventional Endocrinology due to the increasing challenges in using growth hormone. Secretagogues are seen as a logical first step before resorting to injectable growth hormone. The lecture emphasizes the efficacy of secretagogues, highlighting that in cases where the pituitary is involved, injectable growth hormone may be necessary. The regulations surrounding the use of growth hormone are strict, with requirements for challenge tests before prescribing. The cost considerations and efficacy of secretagogues are also addressed, noting the different pathways they target to stimulate growth hormone production.
- Secretagogues are recommended as the first step before using injectable growth hormone
- Challenge tests are required before prescribing growth hormone
- Regulations for growth hormone use are stringent
- Secretagogues target different pathways to stimulate growth hormone production
 
I've been considering adding Sermorelin to my TRT protocol. From what I've read it's beneficial to include a GHRP. What I don't understand is why there are so many varied mixtures of GHRH and GHRP. Can someone shed some light on this for me? Thanks
 
I've been considering adding Sermorelin to my TRT protocol. From what I've read it's beneficial to include a GHRP. What I don't understand is why there are so many varied mixtures of GHRH and GHRP. Can someone shed some light on this for me? Thanks

Much of it according to my reading has to do with half-life in the body. Others have affects on appetite, or cortisol, gastric motility, etc etc. You kind of have to read each one and evaluate it. They also complement each other and work in synergy together. What I found that I am trying is MOD GRF 1 (or CJC 1295 w/o DAC) plus GHRP 2.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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