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I have high total T at the trough (841), but using the dialysis method my free T is only one percent (84)  My E2 is a little above midrange, but my doctor thinks only about total T and never discusses free T.  I told him I am more interested in free T, since total T is doing nothing for me.  I do injections every five days and only do 40mg.  Some people are very sensitive to using TRT.  I am trying to get my free T up, but I cannot think of anyway to do it unless I increase the dose or do injections with a lower dose but say every three days.