I've addressed this in another forum.
You have to have a look at the whole methylation process, not just one pathway, as they work all together synergically. It's the same thing as with the hormones.
For instance, even if you have a COMT upregulation, but a CBS upregulation too (like me) you will end up with even more anxiety adding 5-HTP in the mix, as it raises cortisol.
Also, having a down-regulated COMT (like me again) doesn't mean you are doing well in terms of dopamine and serotonine levels, as you could have a MAOA and VDR down-regulation (guess who?) leading to lower levels in the brain.
Genomic tests are quite complicated to interpret and I never met 2 doctors agreeing on something here, as we are still in early stages and 95% of the doctors don't have a clue of what they are talking about.
