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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Why Can't I Tolerate TRT From a Mental Standpoint?
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<blockquote data-quote="Appassionato" data-source="post: 142335" data-attributes="member: 37892"><p>I've addressed this in another forum.</p><p>You have to have a look at the whole methylation process, not just one pathway, as they work all together synergically. It's the same thing as with the hormones.</p><p>For instance, even if you have a COMT upregulation, but a CBS upregulation too (like me) you will end up with even more anxiety adding 5-HTP in the mix, as it raises cortisol.</p><p></p><p>Also, having a down-regulated COMT (like me again) doesn't mean you are doing well in terms of dopamine and serotonine levels, as you could have a MAOA and VDR down-regulation (guess who?) leading to lower levels in the brain.</p><p></p><p>Genomic tests are quite complicated to interpret and I never met 2 doctors agreeing on something here, as we are still in early stages and 95% of the doctors don't have a clue of what they are talking about.</p></blockquote><p></p>
[QUOTE="Appassionato, post: 142335, member: 37892"] I've addressed this in another forum. You have to have a look at the whole methylation process, not just one pathway, as they work all together synergically. It's the same thing as with the hormones. For instance, even if you have a COMT upregulation, but a CBS upregulation too (like me) you will end up with even more anxiety adding 5-HTP in the mix, as it raises cortisol. Also, having a down-regulated COMT (like me again) doesn't mean you are doing well in terms of dopamine and serotonine levels, as you could have a MAOA and VDR down-regulation (guess who?) leading to lower levels in the brain. Genomic tests are quite complicated to interpret and I never met 2 doctors agreeing on something here, as we are still in early stages and 95% of the doctors don't have a clue of what they are talking about. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Why Can't I Tolerate TRT From a Mental Standpoint?
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