Which testosterone brand/product for subcutaneous use in Denmark?

MangoDenmark

New Member
Hi :)

I live in Denmark, where there is no knowledge of test subcutaneous. Its all IM here.

My endo is willing to prescribe subcutaneus testosterone for me, but this formula of testosterone is not available on pharmacies is Denmark I have to get it from either Germany or Croatia.

Could anyone help me with a productname for different subcutaneous testosterone injection formulas ?

Regards Mango
 
The brand name is unimportant (and unlikely to be know to many, if any, members of Excelmale). Given the fact that you live in Europe, testosterone enanthate should be widely available. Testosterone cypionate is usually prescribed in the United States. Testosterone is testosterone; the difference is in the ester-chain. Either will be fine.
 
Hi :)

I live in Denmark, where there is no knowledge of test subcutaneous. Its all IM here.

My endo is willing to prescribe subcutaneus testosterone for me, but this formula of testosterone is not available on pharmacies is Denmark I have to get it from either Germany or Croatia.

Could anyone help me with a productname for different subcutaneous testosterone injection formulas ?

Regards Mango
Hello - I live in Denmark too, and I 'm having the same issue. did you get any update on your case?
På forhånd tak.
 
Use testosterone enanthate 50 mg twice per week subcutaneously or shallow IM.


Testosterone Esters Available in Denmark:

A Comprehensive Analysis of Therapeutic Options

This comprehensive analysis examines the various testosterone ester formulations currently available in Denmark for testosterone replacement therapy. The Danish pharmaceutical market offers several distinct testosterone preparations, ranging from long-acting injectable formulations to topical gels, each designed to address different patient needs and treatment preferences. The primary testosterone esters available include testosterone undecanoate in multiple brand formulations, mixed testosterone ester combinations, testosterone enanthate, and various topical testosterone preparations, all regulated for the treatment of confirmed male hypogonadism[1][2][3].

Injectable Testosterone Undecanoate Formulations

Long-Acting Testosterone Undecanoate
The most prevalent long-acting testosterone preparation in Denmark is testosterone undecanoate, available under multiple brand names including Nebido, Testonur, Testosteron "Medical Valley," and Testosterone "Teva"[2][3][4][5]. Each formulation contains 1000 mg testosterone undecanoate per 4 ml dose, equivalent to 631.5 mg of pure testosterone[2][3]. This represents a significant advancement in testosterone replacement therapy due to its extended dosing interval.

The standard dosing protocol for testosterone undecanoate involves deep intramuscular injection into the gluteal region every 10-14 weeks[2][3][4]. The interval between the first and second dose may be reduced to a minimum of six weeks to achieve optimal serum testosterone levels more rapidly[2]. The injection must be administered very slowly and deeply intramuscularly due to the risk of pulmonary microembolism associated with the oil-based solution[2][3][4].

Clinical Pharmacokinetics and Monitoring
Following intramuscular administration of 750 mg testosterone undecanoate, serum testosterone concentrations reach maximum levels after a median of seven days, ranging from four to 42 days, which then slowly decline[6]. Steady-state serum testosterone concentration is typically achieved with the third injection at 14 weeks[6]. The mean maximum concentration is approximately 90.9 ng/dL on the fourth day following injection[6]. At 42 days post-injection, testosterone undecanoate becomes nearly undetectable in the serum[6].

Long-term treatment requires individualized dosing based on clinical response, serum testosterone monitoring, and hematocrit assessment[2][3][4]. The treatment is generally considered lifelong for patients with confirmed testosterone deficiency[1]. Clinical studies have demonstrated that quarterly intramuscular injections with long-acting testosterone undecanoate provide stable serum testosterone levels, though experience in elderly patients remains limited due to insufficient safety and feasibility studies[7].

Mixed Testosterone Ester Combinations
Sustanon 250 Formulation
Sustanon 250 represents a sophisticated approach to testosterone replacement therapy, containing a precise blend of four different testosterone esters designed to provide both immediate and sustained testosterone release[8][9]. The active components include testosterone propionate, testosterone decanoate, testosterone phenylpropionate, and testosterone isocaproate[9]. This combination allows for a more stable testosterone release profile compared to single-ester preparations.

The formulation is designed to provide sustained testosterone levels over extended periods, typically requiring injections every 2-3 weeks depending on individual patient response[8]. The mixed ester composition enables both rapid onset of action through the shorter-acting esters and prolonged therapeutic effect through the longer-acting components[8]. This dual-phase release mechanism helps maintain more consistent serum testosterone levels and may improve patient compliance compared to more frequent dosing regimens.

Clinical Efficacy and Performance Effects
Recent research has investigated the acute performance-enhancing effects of mixed testosterone esters. A randomized, double-blind, placebo-controlled study found that a single intramuscular injection of 250 mg mixed testosterone esters did not enhance vertical jump height, peak power, mean power, fatigue index in cycle sprints, or maximal voluntary contraction strength 24 hours post-injection in recreationally active young men[10][11]. This finding suggests that acute ergogenic effects may not occur immediately following testosterone administration, which has important implications for both therapeutic use and anti-doping considerations[10].

Testosterone Enanthate Preparations

Formulation and Clinical Application
Testosterone enanthate is available in Denmark as a 250 mg/10 ml injectable preparation[12]. This ester provides a slower release profile compared to shorter-acting testosterone preparations but requires more frequent administration than testosterone undecanoate[12]. The typical injection schedule ranges from every 1-2 weeks, making it an intermediate option between short-acting and ultra-long-acting testosterone preparations[12].

Testosterone enanthate functions by binding to androgen receptors in muscle cells and other tissues, stimulating protein synthesis and leading to increased muscle growth and strength[12]. The ester modification allows for improved nitrogen retention in muscles, helping to maintain and build muscle mass while providing stable testosterone levels over extended periods[12]. This formulation is particularly popular among patients who prefer more frequent monitoring and dose adjustments compared to the ultra-long-acting preparations.

Topical Testosterone Formulations
Gel-Based Testosterone Preparations
Denmark offers several topical testosterone formulations, providing an alternative to injectable preparations for patients who prefer non-invasive administration routes[13][14][15]. The available topical preparations include Testogel, Androgel, Testavan, and Tostran, with concentrations ranging from 16.2 mg/g to 50 mg per dose[14]. These gel formulations allow for daily application and provide more physiological testosterone replacement patterns.
Testogel and Androgel contain testosterone in a gel base that is applied evenly to the skin, typically on the shoulders, arms, or abdomen[13]. The gel is rapidly absorbed through the skin, providing steady testosterone levels throughout the day[13]. The typical dosing range for topical preparations is 10-20 mg daily, though this may be adjusted based on individual patient response and serum testosterone monitoring[15].

Absorption and Clinical Considerations
Topical testosterone preparations offer several advantages, including avoidance of first-pass hepatic metabolism and the ability to discontinue treatment rapidly if adverse effects occur[13]. The transdermal route provides more physiological hormone replacement, mimicking the natural circadian rhythm of testosterone production more closely than long-acting injectable preparations[13]. However, topical preparations require daily application and carry risks of transfer to close contacts, particularly women and children[13].

Regulatory Framework and Clinical Indications

Approved Indications and Patient Selection
All testosterone preparations available in Denmark are indicated exclusively for substitution treatment in adult males with confirmed testosterone deficiency, as evidenced by both clinical symptoms and laboratory analyses[1][2][3][4][5]. The clinical symptoms that warrant testosterone replacement therapy include impotence, infertility, decreased libido, fatigue, depressive moods, and bone loss caused by low hormone levels[16]. Testosterone replacement therapy is not approved for age-related hypogonadism or performance enhancement in healthy individuals[6].
The diagnostic workup requires confirmation of testosterone deficiency through two separate blood testosterone measurements, along with the presence of characteristic clinical symptoms[16]. Primary hypogonadism may result from testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, chemotherapy, or toxic damage[6]. Secondary hypogonadism involves gonadotropin or LHRH deficiency, often resulting from pituitary-hypothalamic injury from tumors, trauma, or radiation[6].

Contraindications and Safety Considerations

Testosterone therapy is absolutely contraindicated in patients with prostate cancer, liver tumors, or breast carcinoma[2][3][4][5]. While testosterone treatment is unlikely to cause prostate cancer, it can stimulate existing prostate cancer cells to increased growth, necessitating thorough prostate cancer screening before initiating treatment[2][3][4]. Additional contraindications include severe heart-kidney insufficiency, and testosterone preparations must not be used by women due to the risk of virilization[2][3][4].
Special caution is required in patients with ischemic heart disease, circulatory insufficiency, coagulation disorders, thrombophilia, or risk factors for venous thromboembolism[2][3][4]. In patients with severely reduced renal function (GFR <30 ml/min), close monitoring is recommended, and treatment should be discontinued immediately if serious complications such as edema with or without congestive heart failure occur[2][3][4].

Clinical Monitoring and Long-Term Management

Laboratory Monitoring Requirements
Long-term testosterone replacement therapy requires comprehensive monitoring to ensure therapeutic efficacy while minimizing adverse effects[2][3][4]. Regular assessment includes serum testosterone levels to maintain concentrations within the normal physiological range, hematocrit monitoring due to testosterone's stimulation of red blood cell production, and periodic evaluation of prostate health through digital rectal examination and prostate-specific antigen measurement[2][3][4].

Therapeutic doses of testosterone suppress luteinizing hormone (LH) and consequently endogenous androgen production in men[1]. Follicle-stimulating hormone (FSH) suppression may also occur, potentially leading to inhibition of spermatogenesis and resulting infertility, though this effect is usually reversible upon discontinuation of treatment[1]. Studies have demonstrated that testosterone ester injection significantly elevates serum testosterone levels while reducing LH concentrations and increasing estradiol levels[11].

Treatment Duration and Discontinuation
For patients with confirmed testosterone deficiency, replacement therapy is typically considered lifelong[1]. The effects on symptoms of testosterone deficiency occur from a few weeks to several months after treatment initiation[1]. In cases of congenital testicular insufficiency or constitutional delayed puberty, treatment is initiated during puberty, with total testicular function absence requiring pubertal induction usually beginning around age 12, depending on growth, bone age, and developmental factors[1].

Dependency and withdrawal symptoms may occur with significant dose reduction or sudden discontinuation of testosterone therapy[2][3][4]. Therefore, any changes to treatment regimens should be carefully managed under medical supervision, with gradual dose adjustments when modifications are necessary[2][3][4].

Conclusion
Denmark provides a comprehensive range of testosterone ester formulations to address varying patient needs in testosterone replacement therapy. The available options include ultra-long-acting testosterone undecanoate preparations for maximum convenience, mixed testosterone ester combinations for balanced release profiles, testosterone enanthate for intermediate-duration therapy, and topical formulations for patients preferring non-invasive administration. Each formulation offers distinct advantages in terms of dosing frequency, pharmacokinetics, and patient preference, allowing for personalized treatment approaches based on individual clinical circumstances. The regulatory framework ensures appropriate patient selection through mandatory confirmation of testosterone deficiency via both clinical symptoms and laboratory testing, while comprehensive monitoring protocols help maintain therapeutic efficacy and safety throughout long-term treatment. Healthcare providers must carefully consider patient-specific factors, contraindications, and monitoring requirements when selecting the most appropriate testosterone ester formulation for each individual patient requiring testosterone replacement therapy.


1. Androgener - information til sundhedsfaglige - Medicin.dk
2. Nebido - information til sundhedsfaglige - Medicin.dk
3. Testonur - information til sundhedsfaglige - Medicin.dk
4. Testosteron "Medical Valley" - information til sundhedsfaglige - Medicin.dk
5. Testosterone "Teva" - information til sundhedsfaglige - Medicin.dk
6. https://go.drugbank.com/drugs/DB13946
7. https://onlinelibrary.wiley.com/doi/10.1111/andr.13124
8. Køb Sustanon 250 mg/10 ml i Danmark | Livsapotek
9. Sustanon 250 (10 ampere (1 ml (250 mg/ml))) Danmark
10. An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men - PubMed
11. An Intramuscular Injection of Mixed Testosterone Esters Does Not Acutely Enhance Strength and Power in Recreationally Active Young Men - PMC
12. Køb Testosteron Enanthate 250 i Danmark | Livsapotek
13. Køb Androgel (Testogel) uden recept online i Danmark - DKMEDS
14. Testosteron - information til sundhedsfaglige - Medicin.dk
15. Kontakt os: Kundesupport og forespørgsler
16. NEBIDO 1000MG/4ML SOLUTION FOR INJECTION | Drugs.com

Above content from Perplexity Deep Research
 
 

Online statistics

Members online
3
Guests online
161
Total visitors
164

Latest posts

Back
Top