What type of injectible B12 is best?

You Gonna Learn Today · Mar 31, 2016

I believe there are 4 types of injectible B12:

Methylcobalamin
Cyanocobalamin
Hydroxocobalamin
Adenosylcobalamin

What kind is the most effective for energy boost, fat burning and mental clarity/focus? And also, is it ok to take any of these while on TRT?

Fireproof · Mar 31, 2016

Methylcobalamin (B12) - Supplementing with methylcobalamin while following a low calorie diet can increase alertness and energy, as well as supply the body with what it needs for healthy cellular growth and function. Vegetarians especially benefit from methylcobalamin since this compound tends to be prevalent in meat proteins. Also known as vitamin B12, Methylcobalamin is the most bio-available form which means it is readily absorbed and used by the body once injected. Many over the counter B12 supplements consist of Cyanocobalamin, also a cobalamin, which must first convert to methylcobalamin within the liver for the body to have any use for it. Methylcobalamin is a cobalamin used in the treatment of diabetic neuropathy. Methylcobalamin has been advocated to protect the cognitive function of patients suffering from depression, chronic fatigue syndrome, stroke, and ALS.

Vince · Mar 31, 2016

I use

You Gonna Learn Today · Mar 31, 2016

Vince said:
I use

Thanks, Vince. Does this work just as well as the injection type?

CoastWatcher · Mar 31, 2016

https://www.excelmale.com/forum/sho...12-Information-and-Dosing&highlight=Jasen+b12

Injections of b12 have superior absorption as opposed to oral administration. Excellent material on this vitamin is on the Forum.

HarryCat · Mar 31, 2016

Dr. Mariano has stated the sublingual B12 can achieve levels equivalent to injections at a fraction of the cost. Trick is not to chew those Jarrow lozenges. Stick them in you cheek or under your tongue and let them sit there. They usually last at least 30 minutes for me.

Jackie Treehorn · Mar 31, 2016

You Gonna Learn Today said:
I believe there are 4 types of injectible B12:

Methylcobalamin
Cyanocobalamin
Hydroxocobalamin
Adenosylcobalamin

What kind is the most effective for energy boost, fat burning and mental clarity/focus? And also, is it ok to take any of these while on TRT?

If you're thinking of pinning B12 (Methylcobalamin), you might as well pin Lipo-C instead. Check it out at Defy. All of the bennies of B12 plus more.

http://defymedical.com/video-education/health-articles/1-the-next-generation-of-fat-loss-injections

torrential · Mar 31, 2016

+1 on Jarrow sublingual.

Even though injections are fun, if you want to improve B12 levels sublingual is by far the most effective method. The study in the thread linked above looked at oral, meaning swallowed. It's well known that B-12 is poorly adsorbed in the gut so of course injection fared better in that comparison.

Just remember to let it dissolve under your tongue or upper lip. Give it at least 45 minutes and set it so you don't end up swallowing a lot of juice. Typical absorption rate is 25-40%, meaning of the 5,000mcg 1,250 to 2,000 will be picked up and used by your body.

You Gonna Learn Today · Mar 31, 2016

Jackie Treehorn said:
If you're thinking of pinning B12 (Methylcobalamin), you might as well pin Lipo-C instead. Check it out at Defy. All of the bennies of B12 plus more.

http://defymedical.com/video-education/health-articles/1-the-next-generation-of-fat-loss-injections

Thanks, Jackie. Contacting Defy for more details.

maxadvance · Mar 31, 2016

torrential said:
+1 on Jarrow sublingual.

Even though injections are fun, if you want to improve B12 levels sublingual is by far the most effective method. The study in the thread linked above looked at oral, meaning swallowed. It's well known that B-12 is poorly adsorbed in the gut so of course injection fared better in that comparison.

Just remember to let it dissolve under your tongue or upper lip. Give it at least 45 minutes and set it so you don't end up swallowing a lot of juice. Typical absorption rate is 25-40%, meaning of the 5,000mcg 1,250 to 2,000 will be picked up and used by your body.

Please share this study you refer to that shows sublingual is "by far" a better method with higher absorption than injectables

Nelson Vergel · Apr 30, 2025

Thread 'What Type of B-12 Vitamin is Best?'

Apr 30, 2025

“Best” depends on what problem you’re solving, how often you want to inject, and what your pharmacy/insurer will actually supply.

Below is a head-to-head snapshot followed by practical guidance.

Feature	Hydroxocobalamin	Cyanocobalamin	Methylcobalamin
Regulatory status (U S.)	FDA-approved Rx	FDA-approved Rx	Not FDA-approved (503A/503B compounded)
Typical concentration	1 mg/mL (10 mL vial or single ampule)	1 mg/mL (30 mL MDV)	5-25 mg/mL...