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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
What to expect from Armour thyroid meds?
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<blockquote data-quote="DragonBits" data-source="post: 126349" data-attributes="member: 18023"><p>I do see recent, meaning 2017-2018, information on reverse T3.</p><p></p><p>It is reported to have an effect on the brain, but honestly I don't know what it means.</p><p></p><p>There is no credible scientific evidence that rT3 enters the nucleus of the cell at all, and the bulk of the scientific literature states clearly that rT3 does not bind to, and has no known transcriptional activity at, the thyroid receptor. <strong>It is, however, known to have potent activity in the cytoplasm as an initiator of actin polymerization in astrocytes in the brain [7]. This is mediated in a non-genomic manner by its binding to a very specific thyroid receptor that exists only in the extranuclear compartment. Actin polymerization is important to cell structure and motility, and particularly important to normal brain development. </strong></p><p></p><p><a href="http://blog.zrtlab.com/clearing-up-the-confusion-about-reverse-t3-the-role-of-reverse-t3-in-thyroid-assessment" target="_blank">Clearing up the Confusion about Reverse T3: Part 2. The Role of Reverse T3 in Thyroid Assessment</a></p><p></p><p>Reverse T3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: Insight on signaling mechanisms.</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pubmed/29155306" target="_blank">Reverse T3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: Insight on signa... - PubMed - NCBI</a></p><p></p><p>rT3 might be beneficial for brain function</p><p></p><p><a href="https://forums.phoenixrising.me/index.php?threads/rt3-might-be-beneficial-for-brain-function.60190/" target="_blank">rT3 might be beneficial for brain function</a></p><p></p><p>But I don't know what " actin polymerization in astrocytes in the brain" really means. And it seems to be more important during brain development.</p><p></p><p>If anyone has a clue what that means, please educate me.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 126349, member: 18023"] I do see recent, meaning 2017-2018, information on reverse T3. It is reported to have an effect on the brain, but honestly I don't know what it means. There is no credible scientific evidence that rT3 enters the nucleus of the cell at all, and the bulk of the scientific literature states clearly that rT3 does not bind to, and has no known transcriptional activity at, the thyroid receptor. [B]It is, however, known to have potent activity in the cytoplasm as an initiator of actin polymerization in astrocytes in the brain [7]. This is mediated in a non-genomic manner by its binding to a very specific thyroid receptor that exists only in the extranuclear compartment. Actin polymerization is important to cell structure and motility, and particularly important to normal brain development. [/B] [URL='http://blog.zrtlab.com/clearing-up-the-confusion-about-reverse-t3-the-role-of-reverse-t3-in-thyroid-assessment']Clearing up the Confusion about Reverse T3: Part 2. The Role of Reverse T3 in Thyroid Assessment[/URL] Reverse T3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: Insight on signaling mechanisms. [URL='https://www.ncbi.nlm.nih.gov/pubmed/29155306']Reverse T3 interacts with αvβ3 integrin receptor and restores enzyme activities in the hippocampus of hypothyroid developing rats: Insight on signa... - PubMed - NCBI[/URL] rT3 might be beneficial for brain function [URL='https://forums.phoenixrising.me/index.php?threads/rt3-might-be-beneficial-for-brain-function.60190/']rT3 might be beneficial for brain function[/URL] But I don't know what " actin polymerization in astrocytes in the brain" really means. And it seems to be more important during brain development. If anyone has a clue what that means, please educate me. [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
What to expect from Armour thyroid meds?
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