WHAT MEN SHOULD KNOW ABOUT TESTICULAR SHRINKAGE AND TESTOSTERONE THERAPY

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madman

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If you're considering testosterone replacement therapy, understanding its effects on testicular size is crucial. Learn why shrinkage occurs, the treatments available to mitigate this side effect, and why testicle size usually has minimal impact on your overall health. Urologist John Smith, MD, delves into these aspects to provide a comprehensive view.


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Defy Medical TRT clinic doctor

As you can see the abundance of seminiferous tubules/germinal epithelium (where sperm is produced) accounts for 80% of testicular volume.

The use of exogenous testosterone will shut down the HPTA/LH/FSH/iTT (intratesticular testosterone) resulting in atrophy of these tubules.

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Now you can see why atrophy of the testes can be significant in some cases when using/abusing testosterone/AAS.

Fig. 9 Testicular atrophy in a 30-year-old AAS abuser (right) compared to normal size (left)
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Figure 2: Ontogeny of the evolution of testicular volume from birth to adulthood. Seminiferous cords (Sertoli cells + germ cells) are the main component of the testes. From birth and during the prepubertal period (i. e., until 9–14, Tanner stage 1), the volume of seminiferous cords is determined by Sertoli cells, whereas germ cell proliferation determines testicular volume during puberty (i. e., Tanner stages 2 to 5) (adult spermatogenesis). This Figure was modified using BioRender (Scientific Image and Illustration Software | BioRender) under the authorization of[1]. © 2019 Elsevier Ltd

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