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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
What is the reason that nandrolone causes depression? (Mechanism of action)
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<blockquote data-quote="Gman86" data-source="post: 267732" data-attributes="member: 15043"><p>It’s just so interesting how nandrolone solo can make guys feel even better than they do on test, mood wise, energy wise, sexually, etc. So it’s hard to think that nandrolone itself has a negative effect on dopamine</p><p></p><p>The reports of nandrolone making guys depressed and/ or having sexual issues, come mostly from guys using a test base, and adding nandrolone in. So it seems like the issue is mixing nandrolone and test together, not so much the nandrolone itself.</p><p> </p><p>So if this in fact is the case, I’m just trying to figure out what mechanisms are responsible for this. Could it in fact be that nandrolone can increase a persons aromatization rate, as well as making estrogen receptors more sensitive? and anytime estrogen goes up, prolactin tends to go up as well. And I believe that nandrolone increases prolactin receptor sensitivity as well. I think it’s reasonable to theorize that increased E2/ prolactin levels, as well as those hormone levels having a stronger effect at the receptor level, can cause mood and sexual issues. Especially considering that prolactin and dopamine have an inverse relationship</p><p></p><p>it would make sense if something like prami resolved these side effects. It would also make sense that certain DHT derivatives can help with these symptoms. Since things like primo can decrease E2 and prolactin levels, and if prolactin levels decrease, I would assume dopamine levels would increase a bit</p><p></p><p>again, I just have a hard time with nandrolone itself affecting dopamine negatively, when there’s so many anecdotes of guys using nandrolone by itself, or nandrolone with something that increases estrogen slightly, and feeling better mood wise and sexually, compared to when they use testosterone solo, or test as their base</p><p></p><p>does this make sense? I would love to all work together and brainstorm to try and get to the bottom of this the best that we can. It’s something I’m very interested in figuring out. So would love to hear other guy’s opinions on the matter. This is the best that I could come up with atm. It’s ultimately very perplexing and annoying tho! Lol</p></blockquote><p></p>
[QUOTE="Gman86, post: 267732, member: 15043"] It’s just so interesting how nandrolone solo can make guys feel even better than they do on test, mood wise, energy wise, sexually, etc. So it’s hard to think that nandrolone itself has a negative effect on dopamine The reports of nandrolone making guys depressed and/ or having sexual issues, come mostly from guys using a test base, and adding nandrolone in. So it seems like the issue is mixing nandrolone and test together, not so much the nandrolone itself. So if this in fact is the case, I’m just trying to figure out what mechanisms are responsible for this. Could it in fact be that nandrolone can increase a persons aromatization rate, as well as making estrogen receptors more sensitive? and anytime estrogen goes up, prolactin tends to go up as well. And I believe that nandrolone increases prolactin receptor sensitivity as well. I think it’s reasonable to theorize that increased E2/ prolactin levels, as well as those hormone levels having a stronger effect at the receptor level, can cause mood and sexual issues. Especially considering that prolactin and dopamine have an inverse relationship it would make sense if something like prami resolved these side effects. It would also make sense that certain DHT derivatives can help with these symptoms. Since things like primo can decrease E2 and prolactin levels, and if prolactin levels decrease, I would assume dopamine levels would increase a bit again, I just have a hard time with nandrolone itself affecting dopamine negatively, when there’s so many anecdotes of guys using nandrolone by itself, or nandrolone with something that increases estrogen slightly, and feeling better mood wise and sexually, compared to when they use testosterone solo, or test as their base does this make sense? I would love to all work together and brainstorm to try and get to the bottom of this the best that we can. It’s something I’m very interested in figuring out. So would love to hear other guy’s opinions on the matter. This is the best that I could come up with atm. It’s ultimately very perplexing and annoying tho! Lol [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
What is the reason that nandrolone causes depression? (Mechanism of action)
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