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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
What’s the general consensus on AI’s here?
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<blockquote data-quote="xqfq" data-source="post: 161019" data-attributes="member: 38167"><p>Also, not to get too into the weeds, but RE: that article:</p><ul> <li data-xf-list-type="ul">The reference to E2 raising CRP is, IMO, off base. It references a journal reply that cites the HERS data. All of the data I've looked at has said that E2 <em>lowers</em> CRP, see e.g. <a href="https://link.springer.com/article/10.1007/s11010-012-1482-9" target="_blank">"Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein"</a>. Oral estrogen can increase CRP, but injectable / transdermal doesn't (see e.g. "<a href="https://www.ncbi.nlm.nih.gov/pubmed/12940591" target="_blank">Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation and cellular redox state.</a>").<br /> <br /> </li> <li data-xf-list-type="ul">RE: HERS study in general. You might find <a href="https://peterattiamd.com/caroltavris-avrumbluming/" target="_blank">this recent podcast with the authors of the new book "Estrogen Matters" on female HRT interesting - I know I did</a>!<br /> <br /> </li> <li data-xf-list-type="ul">The other reference is to a study that shows a correlation (not causation) between high e2 in very sick patents with chronic heart failure and risk of death. See e.g. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768161/" target="_blank">Testosterone treatment for men with chronic heart failure</a> for why this is likely to be correlative and not causative.</li> </ul><p>I am not sure that "E2's HDL" is necessarily 100% good, but I don't think the arguments on that page are sound.</p></blockquote><p></p>
[QUOTE="xqfq, post: 161019, member: 38167"] Also, not to get too into the weeds, but RE: that article: [LIST] [*]The reference to E2 raising CRP is, IMO, off base. It references a journal reply that cites the HERS data. All of the data I've looked at has said that E2 [I]lowers[/I] CRP, see e.g. [URL='https://link.springer.com/article/10.1007/s11010-012-1482-9']"Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein"[/URL]. Oral estrogen can increase CRP, but injectable / transdermal doesn't (see e.g. "[URL='https://www.ncbi.nlm.nih.gov/pubmed/12940591']Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation and cellular redox state.[/URL]"). [*]RE: HERS study in general. You might find [URL='https://peterattiamd.com/caroltavris-avrumbluming/']this recent podcast with the authors of the new book "Estrogen Matters" on female HRT interesting - I know I did[/URL]! [*]The other reference is to a study that shows a correlation (not causation) between high e2 in very sick patents with chronic heart failure and risk of death. See e.g. [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1768161/']Testosterone treatment for men with chronic heart failure[/URL] for why this is likely to be correlative and not causative. [/LIST] I am not sure that "E2's HDL" is necessarily 100% good, but I don't think the arguments on that page are sound. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
What’s the general consensus on AI’s here?
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