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I'm on the combination of naltrexone and bupropion (wellbutrin). They do not sell the doses that are listed in above study so I have to break pills and come as close as possible. I'm on 300 mg bupropion and 25 mg naltrexone as 37mg was way to high and I experienced some rather bizarre side effects that quite frankly wouldn't be worth it. I was on wellbutrin in the past at the same dose and it did nothing for my weight.  I don't think Naltrexone alone would be beneficial as I have found it to be sedating and think it could lead to depression. The combo however has been nothing less than remarkable. I have no doubt  that this will become a treatment of choice for those suffering from an eating disorder.  I am exercising less, eating less, and have a heightened sense of awareness.  I am aware of every bite going into my mouth, the texture, the taste and still have a temporary high for maybe a second or two (not a min. or two as before). The only other change is an increase in Testosterone from 150mg to 200mg started same week as naltrexone combo but, the initial 4-5 lbs of the 6lbs of loss I reported was before starting T increase.

So to answer your question, its a combination, but I definitely believe Naltrexone is the driving force.


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