I wonder how you would have done if you had dropped down to 250-500 IU EOD after the initial boost.
I do not understand why "high intra-testicular estrogen" is of any concern. Whatever E2 leaves the testes will be dealt with by AI.
It would be great to know why some men experience a decreasing benefit on hCG mono. The hCG receptors associated with the CNS are strongly suspect in the initial, often powerful, boost to mood cognition, and libido that many report. As theorized, it is the CNS LH receptors which had been starved responding strongly at first. This says nothing of LH receptors in the Leydigs which are responsible for T production.
The hCG Antibody Theory
Two small studies in the early 1980's reported a finding of "developing hCG antibodies" in a few men that the researchers attributed to loss of hCG effectiveness. The discussion of last two decades has been on theoretical Leydig cell fatigue, damage or "down-regulation" based on rat rather than human studies. The first two are a web myth. It's also theorized that excess intra-testicular progesterone from high dose hCG causes the "down-regulation" of the Leydigs.
