Vitamin D & Testosterone: No Impact on Levels in Healthy Men

CoastWatcher

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Previous studies have shown an association of vitamin D and androgen levels in men. However, a recent study from Austria, a randomized control trial, provided conflicting results.

*Please note that the study accepted men with total testosterone levels that any good clinician would classify as hypogonadal. Another example of the disconnect between academic medicine and the world of medical practice.*

  • Men with total testosterone greater than 10.4nmol/l (300 ng/dl) and healthy vitamin D levels were divided into two groups.
  • One group received 20,000 IU of vitamin D per week for 12 weeks while one group received a placebo.
  • Vitamin D treatment had no effect on total testosterone levels in the, so-called, healthy men in this study, but it did have a significant effect on the insulin-check sensitivity index.
  • As is typical, more investigation is being called for.

The Journal of Clinical Endocrinology & Metabolism, 29 August 2017.

https://academic.oup.com/jcem/artic...rone-In-Healthy-Men-A?redirectedFrom=fulltext
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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