Vitamin D supplementation improved muscle pain in women with low estradiol

Nelson Vergel

Founder, ExcelMale.com
Breast cancer is the most prevalent form of cancer in women worldwide. The medications and hormone therapies used to treat breast cancer can result in several side effects, usually due to modification of estrogen production in the body. Similar to the consequences of decreased estrogen production in women going through menopause, breast cancer patients undergoing hormone therapy can experience musculoskeletal symptoms such as joint pain, stiffness, bone pain, muscle pain and muscle weakness.

Aromatase inhibitors (AI) suppress estrogen levels in postmenopausal women with breast cancer by inhibiting the enzyme that activates estrogen production in fat tissue. Letrozole is a type of AI used in breast cancer hormone therapy treatment. Previous studies have shown that musculoskeletal symptoms worsened in patients taking letrozole as a result of vitamin D deficiency and decreased estrogen production. Researchers conducted a recent study to investigate the role that vitamin D3 and calcium supplementation might have on musculoskeletal symptoms in breast cancer patients taking letrozole.





http://www.vitamindcouncil.org/blog...patients/?mc_cid=a3ae68c086&mc_eid=41f41562a9
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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