Nelson Vergel
Founder, ExcelMale.com
CROI: VITAMIN D DEFICIENCY IMPAIRS THE BENEFICIAL EFFECTS OF STATIN IN TREATED HIV - - (04/06/17)
"The correlation between low serum 25-hydroxyvitamin D concentration and statin-induced musculoskeletal pain is debated still today, but it was proved by several observational cohort studies performed in the general population.....The association of low vitamin D levels with statin-induced myalgia in general population was also confirmed by a recent meta-analysis based on an electronic search yielding 437 articles, which investigated the effect of vitamin D levels in statin-treated patients......To conclude, low vitamin D levels seem to be associated with the development of statin-induced myalgia in HIV-infected patients under cART like in the general population, but additional, enlarged, and controlled studies are needed to examine the potential role of vitamin D deficiency in the reduced statin tolerance by HIV-infected people.....Baseline characteristics were similar between patients who experienced muscle toxicity and those who tolerated statin treatment with the exception of age, 25-hydroxyvitamin D concentration, and total duration of statin therapy. Myalgia was significantly more likely to occur in older patients (mean age, 58.6 vs. 52.5 years; P = 0.041).
"The correlation between low serum 25-hydroxyvitamin D concentration and statin-induced musculoskeletal pain is debated still today, but it was proved by several observational cohort studies performed in the general population.....The association of low vitamin D levels with statin-induced myalgia in general population was also confirmed by a recent meta-analysis based on an electronic search yielding 437 articles, which investigated the effect of vitamin D levels in statin-treated patients......To conclude, low vitamin D levels seem to be associated with the development of statin-induced myalgia in HIV-infected patients under cART like in the general population, but additional, enlarged, and controlled studies are needed to examine the potential role of vitamin D deficiency in the reduced statin tolerance by HIV-infected people.....Baseline characteristics were similar between patients who experienced muscle toxicity and those who tolerated statin treatment with the exception of age, 25-hydroxyvitamin D concentration, and total duration of statin therapy. Myalgia was significantly more likely to occur in older patients (mean age, 58.6 vs. 52.5 years; P = 0.041).
