A study found that men with the lowest testosterone levels had reduced risk of prostate cancer, but higher levels were not correlated with cancer risk. This provides evidence for the theory that prostate androgen receptors are saturated at low levels of testosterone.
The researchers divided the 19,000 men into ten groups – ranging from men with the lowest amount of testosterone in their blood to those with the highest, and compared their prostate cancer risk.They found that men in the group with the lowest levels of testosterone were significantly less likely to develop prostate cancer compared to all other men. Yet interestingly, when men in this group do get prostate cancer, they are 65% more likely to develop an aggressive form of the disease compared to all other men. For the men in the remaining nine groups, testosterone was not associated with prostate cancer risk.