Urinary Stones Linked to Testosterone Therapy

Jinzang

Member
From a talk at the annual meeting of the American Urological Association. A news report says:

In a study of 26,585 men aged 40 to 64 years who received continuous TRT matched by birth year, race, marital status and other factors to 26,585 controls with clinical hypogonadism not on TRT, Tyler R. McClintock MD, MS, of Brigham and Women's Hospital and Harvard Medical School in Boston, and colleagues found a significantly higher incidence of urinary stones among TRT recipients. The primary outcome was 2-year absolute risk of a stone-related event, which occurred in 659 men on TRT compared with 482 in the control group.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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