Unveiling the Impact of TRT on Cardiovascular Health

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post #21

*We bring attention to the limitations of the TRAVERSE trial due to the potential for misleading reassurance of the safety of TRT at physiologic or supraphysiologic levels. The long term CV effects and the safety of such regimens have yet to be studied. We certainly advocate for further research to explore the long-term CV impact of TRT, especially at these higher dosing levels.

*The debate surrounding TRT and CVD risk thus far can be summarized as follows: current evidence suggests TRT does not increase CVD risk in older, hypogonadal men when administered over a short duration and at low-normal levels of replacement. The question remains open when considering the effects of TRT at physiologic or supraphysiologic levels.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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