Thanks for the response. I take it by supra-physiological, you mean those doing cycles of steroids...not those on TRT, even if they are in the higher natural range such as 1,200 ng/dl.
I'm finding it tough to find solid information on this. I'm guessing it's probably because you can read something clinical in a scientific journal, but when it comes time for your buddies or internet bloggers to back that up as anecdotal experiences, most lifters willing to do this are either natural, heavily-juiced, or on TRT and not willing to admit to it.
Also those on TRT can probably do a cycle if they want it bad enough, then return to TRT levels afterwards to maintain the muscle. So most of those gains are done at that supra-physiological level. Leaving me once again wondering what the best plan is if you are only on TRT.
I just think with the levels of elevated testosterone, there has to be some advantage to how your body reacts. Meaning there has to be some way to take advantage of the condition compared to someone natural doing the exact same thing.
I did see a study that dealt with protein synthesis as you are saying, that concluded:
And the levels didn't seem to be that high. If I'm reading correctly:
edit...I'm going to add this study seems like it was from 1996
