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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TruT Free Testosterone Calculator
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<blockquote data-quote="madman" data-source="post: 235180" data-attributes="member: 13851"><p>For the time being no provider should be using/relying on the cFTZ!</p><p></p><p>Again the data/results from the completion of PHASE II have not even come out yet.</p><p></p><p>FT should be tested using the most accurate assays (ED/UF), especially in cases of altered SHBG.</p><p></p><p></p><p></p><p>Even when using the newer calculated method anyone presenting with symptoms and an FT<16 ng/dL would be considered low.</p><p></p><p><em>In one aspect, described herein is a non-transitory computer-readable storage medium storing one or more programs for determining a need for adjustment of a dose of sex hormone, such as testosterone or estrogen, administered to an individual, the one or more programs for execution by one or more processors of a computer system, the one or more programs comprising instructions for: <strong>a) receiving data from determining the concentration of free sex hormone, such as free testosterone or free estrogen, in an individual receiving sex hormone therapy at a first dose, wherein the concentration of free sex hormone is determined by measuring i) a total SHBG concentration, ii) a total sex hormone concentration, such as total testosterone or estrogen concentration, and iii) a total albumin concentration in a biological sample obtained from an individual, to determine free sex hormone concentration from the individual; b) attributing at least two distinct interconverting microstates of an unliganded SHBG dimer having a first monomer and a second monomer by applying the New Multi-Step Dynamic Binding Model with Complex Allostery to the data of step a); c) calculating the free sex hormone concentration in the individual using the New Multi-step Dynamic Binding Model with Complex Allostery encompassing readjustment of a first equilibria between the microstates upon binding of a first sex hormone molecule to the first monomer and an allosteric interaction between two binding sites of the SHBG dimer, d) <u>sending a signal for providing a second dose of sex hormone that is higher than the first dose when the free sex hormone concentration is below the lower end of the target therapeutic range (e.g. 164 pg/ml); and e) sending a signal for providing a second dose of sex hormone that is lower than the first dose when the free sex hormone concentration is above the upper end of the target therapeutic range (e.g. 314 pg/ml)</u>.</strong> In specification: In another embodiment, the target therapeutic range could vary with the age of the patient, co-morbid conditions, and the types of assays used for measuring total sex hormone, SHBG, and albumin. in which case sending the signal for providing a second dose of sex hormone that is higher than the first dose when the free sex hormone concentration is below the lower end of the target therapeutic range for that age, co-morbid conditions, and assay.</em></p><p><em></em></p><p><em></em></p><p><em><strong>"Based on the new data on the distribution of free testosterone levels in healthy men the <u>target range of free testosterone has been determined to be 164 to 314 pg/ml</u> (mean+/−1SD)"</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>Example 3</strong></em></p><p><em><strong></strong></em></p><p><em><strong>In one aspect, described herein is a personalized exogenous steroid delivery dosimeter. </strong>Time-dependent drug delivery/clearance models can be incorporated with the calculator of free T described herein (FIG. 10). T administration, redistribution, and clearance rates can be accounted for. In some embodiments, an experiment, a model, and a set of parameters are present and the model described herein can be used to obtain results. In some embodiments, a set of datasets and experiments are present, and the model described herein can be used to determine initial model parameters.</em></p><p><em></em></p><p><em><strong>The methods and systems described herein can include the total T level. SHBG level, albumin level, SHBG polymorphisms, clearance rates, circadian rhythms, and metabolism levels. LH level, FSH level, T degradation, T diffusion/permeability coefficient, and release speed.</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>[0029] Fig. 10 depicts a schematic of the control of testosterone levels.</strong></em></p><p><em><strong>[ATTACH=full]26152[/ATTACH]</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>[0030] Fig. 11 depicts a schematic of an exemplary system of determining free testosterone levels and/or dosages.</strong></em></p><p><em><strong>[ATTACH=full]26153[/ATTACH]</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>[0031] Fig. 12 depicts a device or a computer system 1000 comprising one or more processors 1300 and a memory 1500 storing one or more programs 1600 for execution by the one or more processors 1300</strong></em></p><p>[ATTACH=full]26154[/ATTACH]</p></blockquote><p></p>
[QUOTE="madman, post: 235180, member: 13851"] For the time being no provider should be using/relying on the cFTZ! Again the data/results from the completion of PHASE II have not even come out yet. FT should be tested using the most accurate assays (ED/UF), especially in cases of altered SHBG. Even when using the newer calculated method anyone presenting with symptoms and an FT<16 ng/dL would be considered low. [I]In one aspect, described herein is a non-transitory computer-readable storage medium storing one or more programs for determining a need for adjustment of a dose of sex hormone, such as testosterone or estrogen, administered to an individual, the one or more programs for execution by one or more processors of a computer system, the one or more programs comprising instructions for: [B]a) receiving data from determining the concentration of free sex hormone, such as free testosterone or free estrogen, in an individual receiving sex hormone therapy at a first dose, wherein the concentration of free sex hormone is determined by measuring i) a total SHBG concentration, ii) a total sex hormone concentration, such as total testosterone or estrogen concentration, and iii) a total albumin concentration in a biological sample obtained from an individual, to determine free sex hormone concentration from the individual; b) attributing at least two distinct interconverting microstates of an unliganded SHBG dimer having a first monomer and a second monomer by applying the New Multi-Step Dynamic Binding Model with Complex Allostery to the data of step a); c) calculating the free sex hormone concentration in the individual using the New Multi-step Dynamic Binding Model with Complex Allostery encompassing readjustment of a first equilibria between the microstates upon binding of a first sex hormone molecule to the first monomer and an allosteric interaction between two binding sites of the SHBG dimer, d) [U]sending a signal for providing a second dose of sex hormone that is higher than the first dose when the free sex hormone concentration is below the lower end of the target therapeutic range (e.g. 164 pg/ml); and e) sending a signal for providing a second dose of sex hormone that is lower than the first dose when the free sex hormone concentration is above the upper end of the target therapeutic range (e.g. 314 pg/ml)[/U].[/B] In specification: In another embodiment, the target therapeutic range could vary with the age of the patient, co-morbid conditions, and the types of assays used for measuring total sex hormone, SHBG, and albumin. in which case sending the signal for providing a second dose of sex hormone that is higher than the first dose when the free sex hormone concentration is below the lower end of the target therapeutic range for that age, co-morbid conditions, and assay. [B]"Based on the new data on the distribution of free testosterone levels in healthy men the [U]target range of free testosterone has been determined to be 164 to 314 pg/ml[/U] (mean+/−1SD)" Example 3 In one aspect, described herein is a personalized exogenous steroid delivery dosimeter. [/B]Time-dependent drug delivery/clearance models can be incorporated with the calculator of free T described herein (FIG. 10). T administration, redistribution, and clearance rates can be accounted for. In some embodiments, an experiment, a model, and a set of parameters are present and the model described herein can be used to obtain results. In some embodiments, a set of datasets and experiments are present, and the model described herein can be used to determine initial model parameters. [B]The methods and systems described herein can include the total T level. SHBG level, albumin level, SHBG polymorphisms, clearance rates, circadian rhythms, and metabolism levels. LH level, FSH level, T degradation, T diffusion/permeability coefficient, and release speed. [0029] Fig. 10 depicts a schematic of the control of testosterone levels. [ATTACH type="full"]26152[/ATTACH] [0030] Fig. 11 depicts a schematic of an exemplary system of determining free testosterone levels and/or dosages. [ATTACH type="full"]26153[/ATTACH] [0031] Fig. 12 depicts a device or a computer system 1000 comprising one or more processors 1300 and a memory 1500 storing one or more programs 1600 for execution by the one or more processors 1300[/B][/I] [ATTACH type="full"]26154[/ATTACH] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
TruT Free Testosterone Calculator
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