TRT Does Not Degrade — And Sometimes Improves — Arterial Endothelial Function

Jinzang

Member
Testosterone replacement therapy (TRT), which has come under scrutiny recently for a suspected link to cardiovascular disease, improves arterial endothelial function in some men when prescribed for symptomatic hypogonadism, Cleveland Clinic researchers have found.

Data from a study of 20 men treated for at least 3 months with topical TRT or TRT pellets for symptomatic hypogonadism revealed either no change or an improvement in reactive hyperemia index (RHI) and augmentation index (AI), measures of endothelial function and arterial stiffness, compared with pre-therapy, reported Daniel Shoskes, MD, at the American Urological Association’s 2016 annual meeting.

https://consultqd.clevelandclinic.o...terial-endothelial-function-men-hypogonadism/
 
Last edited by a moderator:
....older men with limitations in mobility and a high prevalence of chronic disease.....

says this article. My personal opinion is, you can limited these side effects by living a healthy lifestyle.

We should ask Nelson how many heart attacks he already had due the TRT. ;)
 
says this article. My personal opinion is, you can limited these side effects by living a healthy lifestyle.

Sure, lifestyle has a big effect on heart disease and prostate cancer. And I was encouraged to eat healthy and join a gym by the clinic I use. But it's encouraging to know that TRT decreases the risk of heart disease and prostate cancer, so that TRT and lifestyle change work hand in hand.
 
Sure, lifestyle has a big effect on heart disease and prostate cancer. And I was encouraged to eat healthy and join a gym by the clinic I use. But it's encouraging to know that TRT decreases the risk of heart disease and prostate cancer, so that TRT and lifestyle change work hand in hand.

Excellent points. The notion that testosterone therapy, in and of itself, puts someone at risk for heart disease has been debunked multiple times. But the idea's like the monster in a bad horror movie that won't die.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
6
Guests online
380
Total visitors
386

Latest posts

Back
Top