TRT can delay CKD

Will Brink

Member
interesting finding here, TRT delay progression of chronic kidney disease:

Testosterone replacement therapy (TRT) may delay progression of chronic kidney disease (CKD) and lower the risk of death in men with hypogonadism, new findings presented at the National Kidney Foundation's 2017 Spring Clinical Meetings suggest.

Archana Goel, MD, of the Veterans Administration Medical Center in Kansas City, Missouri, and colleagues analyzed data from a large cohort of veterans diagnosed with low total testosterone (TT). The investigators divided patients into 2 groups: those treated and who had normalization of TT (38,708 men) and those who were not treated (9755 men) and continued to have low TT. The treated and untreated groups had follow-up times of 6.1 and 5.1 years, respectively.

The groups did not differ significantly in the number of days until patients had a 30% or greater increase in serum creatinine or doubling of serum creatinine from baseline, the investigators reported in a poster presentation. The treated group, however, showed a significant delay in the progression of CKD as measured by days to serum creatinine increases of 1.5 or higher and 3.0 mg/dL or higher. TRT delayed the time to end-stage renal disease (ESRD), as defined by a serum creatinine level greater than 6.0 mg/dL) by 284 days and time to death by 328 days. Compared with the untreated men, the treated men had a 24% decreased risk of ESRD and 25% decreased risk of death.

Dr Goel's group concluded that “TRT does not associate with significant disadvantages at earlier stages of CKD, but rather a significant decrease and delay in all-cause mortality and delay in progression toward ESRD.”

Cont:

http://www.renalandurologynews.com/...pJobID=1001805288&spReportId=MTAwMTgwNTI4OAS2
 
Glad to see something positive about testosterone coming from the VA. I know that every 6 months or so I have to be prepared to defend my current usage/dosage. :(
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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