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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT & benzo withdrawal, please help.
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<blockquote data-quote="madman" data-source="post: 266259" data-attributes="member: 13851"><p>Both issues (Benzo and Testosterone) need to be addressed by a competent doctor.</p><p></p><p>Again highly doubtful that your T levels are going to be much better when you come of your current medication.</p><p></p><p>If you were abusing opiods that can have a significant negative impact on the hpta and</p><p>lowering T levels.</p><p></p><p>Even then recovery of T levels in not a long process.</p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/opioid-induced-hypogonadism.25565/[/URL]</p><p></p><p><em><strong>*<u>The impact occurs rapidly, often within one week, and the highest risk appears to be among patients receiving significant dosages for longer than one month</u>. <u>The use</u><em><u> of the more potent opioids is more likely to cause a greater risk of hypogonadism, but the effects seem to be reversible after a few days of withdrawal</u>.</em> As one might expect, long-acting opioids have a greater risk compared with short-acting drugs. There is a significant correlation between increased dosage and the development of opioid-induced androgen deficiency (OPIAD).14</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>The prevalence of OPIAD ranges from 19% to 86%, with most studies reporting an overall prevalence higher than 50%, confirming the significant impact of opioids in reducing testosterone levels</u>.14,17,18 <u>Figure 3</u> shows the prevalence of low testosterone among chronic opioid users and men with other conditions.19</strong></em></p><p></p><p><strong><em>*<u>A systematic review and metaanalysis of testosterone suppression in opioid users concluded that testosterone level was suppressed in men with regular opioid use regardless of the opioid type</u> and found a mean testosterone difference of 5.7nmol/L between opioid users and controls. Opioids were found to affect testosterone levels differently in men than women, and testosterone was not found to be suppressed in studies examining opioid-using women.20</em></strong></p><p></p><p><em><strong>Opioids can induce several hypogonadism-related signs and symptoms, including sexual dysfunction, mood impairment, fatigue, obesity and cardiovascular disease, osteoporosis, and sexual dysfunction.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>Summary</strong></p><p></p><p><em><strong>OPIAD is common and can impair satisfactory pain relief. OPIAD also impairs sexual activity, mood, and bone metabolism and is a risk factor for cardiovascular disease and obesity.</strong></em></p><p></p><p><strong><em><u>Guidelines support screening for testosterone deficiency in this situation</u>.<u> Consideration should be given to screening for testosterone deficiency prior to an opioid prescription, to provide a baseline</u>. From a clinical point of view, the effect is reversible and if the opioid is removed, the deficiency is reversed, usually within a month.</em></strong></p><p></p><p><em><strong>Wherever possible consider alternative pain management strategies, as per NICE guidance, but if treatment is necessary consider using an opioid with a lower MOP affinity such as buprenorphine or tramadol, and enquire about relevant low testosterone symptoms, with testosterone measurements at subsequent follow-up</strong></em></p><p></p><p><strong><em>Current evidence suggests testosterone replacement might be beneficial and synergistic with analgesics to improve pain control in hypogonadal men.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>OPIAD can have a profound effect on health and quality of life, and it can hinder a clinician’s ability to effectively treat chronic pain and manage complex comorbidities, but it often goes unrecognized and untreated.</em></strong></p><p></p><p></p><p></p><p></p><p>You are 49 years old and your FT level is dismal.</p><p></p><p>Again you were given sound advice regarding your low T.</p><p></p><p>I never stated how to go about addressing you coming of your current medication other than seeking out a competent doctor!</p></blockquote><p></p>
[QUOTE="madman, post: 266259, member: 13851"] Both issues (Benzo and Testosterone) need to be addressed by a competent doctor. Again highly doubtful that your T levels are going to be much better when you come of your current medication. If you were abusing opiods that can have a significant negative impact on the hpta and lowering T levels. Even then recovery of T levels in not a long process. [URL unfurl="true"]https://www.excelmale.com/forum/threads/opioid-induced-hypogonadism.25565/[/URL] [I][B]*[U]The impact occurs rapidly, often within one week, and the highest risk appears to be among patients receiving significant dosages for longer than one month[/U]. [U]The use[/U][I][U] of the more potent opioids is more likely to cause a greater risk of hypogonadism, but the effects seem to be reversible after a few days of withdrawal[/U].[/I] As one might expect, long-acting opioids have a greater risk compared with short-acting drugs. There is a significant correlation between increased dosage and the development of opioid-induced androgen deficiency (OPIAD).14 *[U]The prevalence of OPIAD ranges from 19% to 86%, with most studies reporting an overall prevalence higher than 50%, confirming the significant impact of opioids in reducing testosterone levels[/U].14,17,18 [U]Figure 3[/U] shows the prevalence of low testosterone among chronic opioid users and men with other conditions.19[/B][/I] [B][I]*[U]A systematic review and metaanalysis of testosterone suppression in opioid users concluded that testosterone level was suppressed in men with regular opioid use regardless of the opioid type[/U] and found a mean testosterone difference of 5.7nmol/L between opioid users and controls. Opioids were found to affect testosterone levels differently in men than women, and testosterone was not found to be suppressed in studies examining opioid-using women.20[/I][/B] [I][B]Opioids can induce several hypogonadism-related signs and symptoms, including sexual dysfunction, mood impairment, fatigue, obesity and cardiovascular disease, osteoporosis, and sexual dysfunction.[/B][/I] [B]Summary[/B] [I][B]OPIAD is common and can impair satisfactory pain relief. OPIAD also impairs sexual activity, mood, and bone metabolism and is a risk factor for cardiovascular disease and obesity.[/B][/I] [B][I][U]Guidelines support screening for testosterone deficiency in this situation[/U].[U] Consideration should be given to screening for testosterone deficiency prior to an opioid prescription, to provide a baseline[/U]. From a clinical point of view, the effect is reversible and if the opioid is removed, the deficiency is reversed, usually within a month.[/I][/B] [I][B]Wherever possible consider alternative pain management strategies, as per NICE guidance, but if treatment is necessary consider using an opioid with a lower MOP affinity such as buprenorphine or tramadol, and enquire about relevant low testosterone symptoms, with testosterone measurements at subsequent follow-up[/B][/I] [B][I]Current evidence suggests testosterone replacement might be beneficial and synergistic with analgesics to improve pain control in hypogonadal men. OPIAD can have a profound effect on health and quality of life, and it can hinder a clinician’s ability to effectively treat chronic pain and manage complex comorbidities, but it often goes unrecognized and untreated.[/I][/B] You are 49 years old and your FT level is dismal. Again you were given sound advice regarding your low T. I never stated how to go about addressing you coming of your current medication other than seeking out a competent doctor! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
TRT & benzo withdrawal, please help.
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