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One thing that I had that and sometimes I would have one large lymph node then it would go down then another would pop up. I have seen this in some thyroid groups people talking about this as well.   What it was was Hashimoto's Thyroiditis.  I have not had that in years but I had it for years. I am on Low Dose Naltrexone now and I am actually treated for low thyroid. I would get if it were me both thyroid antibodies tested tpo and tg ab  and I would get tsh but also free t3 and free t4 a total t3 and total t4.   would be nice as well.  

As far as reactions go, I  knew one guy who had a reaction to the cotton seed and broke out in a rash all over his body but that was the only guy I knew. A lot of things can cause the lymphnode issues.