Treating Low Sexual Desire in the Post-Menopausal Woman

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At the present tine. flibanserin (Addyi, Valeant Pharmaceuticals) is the only approved therapy for hypoactive sexual desire disorder in women. However, it is only indicated for use in premenopausal women.

According to Dr. Sheryl Kingsberg, hypoactive sexual desire disorder is the most prevalent sexual dysfunction of women of all ages, but the highest rates are among postmenopausal women. Data presented by Kingsberg revealed that flibanserin was more effective than placebo in improving not only the desire domain on the Female Sexual Function Index, as previously reported by results from the Snow Drop Trial, but also improves all domains related to sexual function.

"Fibanserin May Be Effective Treatment For Hypoactive Sexual Desire in Post-Menopausal Women," Healio, Endocrine Today, 12 October 2017

https://www.healio.com/endocrinolog...exual-desire-disorder-in-postmenopausal-women
 

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Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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