Transdermal Question

galaxy

Member
Hello - In Nelson's sticky regarding TRT Options dated 2014 he mentions the following:

"Some doctors do not feel comfortable prescribing gels from compounding pharmacies since they worry about quality control. There is also concern that higher concentration gels may induce more DHT conversion, which may cause more prostatic hyperplasia (inflammation) causing urinary flow restrictions especially in older men. Also, higher DHT can cause acne and hair loss."




I was wondering if there's been any resolution surrounding the concern regarding high concentration creams and DHT. I remember reading about multiple forum members both here and on PeakT who mentioned that the 1-2% brand strength didn't really do much and that switching to 20% creams from EmpowerRx really made a difference. Has the concern regarding DHT changed much? I guess this can be something to monitor while on it.
 
Cream and gels definitely increase DHT, some men prefer them and like the increase of DHT. We have many good threads on the subject. Personally I refuse to do them because I'm afraid of contaminating my grandkids or my lover.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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