Toremefine (Fareston - SERM) for low SHBG instead of AI?

Elnico50

New Member
Have found some information while browsing on this SERM. One of the negative side effects most commonly brought up is that it raises SHBG. However, for those that have low SHBG such as myself..... wondering if this could this be of benefit ?

Other benefits are listed as reversing/preventing gyno, lowering estrogen levels in general and enhanced libido.

Any thoughts on this?
 
Be mindful that toremifene carries a small, yet substantial, risk of a potentially fatal cardiac arrhythmia ("Torsades de Pointes"), especially in folks with QT segment prolongation on EKG. There is a blackbox warning for this reason. To be safe, get an EKG performed before considering this SERM.
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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