The Testosterone Revolution: Why Modern Men Are Redefining Health, Strength, and Longevity

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[42:22] — When rising testosterone doesn’t fix symptoms
[43:24] — Free testosterone vs. total testosterone





In this episode, Dr. Jesse Mills, Director of the UCLA Men’s Clinic, joins Mike Haney to explain what’s driving that shift and what today’s data-driven approach to men’s health looks like.

He breaks down the testosterone “revolution,” what’s really happening in low-T diagnoses, and how lifestyle, sleep, and stress management can influence hormones as much as prescriptions can.




They discuss:

  • How men’s health became its own medical discipline
  • What testosterone really does—and how to know if it’s low
  • Primary vs. secondary hypogonadism and how to tell the difference
  • When testosterone replacement is appropriate (and when it’s not)
  • Why younger men are now embracing prevention and optimization



What Dr. Jesse Mills & Mike Haney discuss

:[2:10] — How men’s health became its own field
[8:05] — Why younger men are finally talking about sexual health
[12:00] — Testosterone 101: how the system actually works
[18:45] — When low testosterone is reversible through lifestyle
[26:50] — Why we need “forensic endocrinology” to interpret labs
[42:22] — When rising testosterone doesn’t fix symptoms
[43:24] — Free testosterone vs. total testosterone
[52:33] — The importance of PSA screening before TRT
[1:02:18] — Testosterone delivery methods and how they change physiology
[1:06:27] — The hidden risks of testosterone gels[
1:14:51] — The #1 rule of testosterone evaluation: find reversible causes

[1:23:56] — How MRI transformed prostate cancer detection
[1:27:57] — The USPSTF screening mistake and its consequences
[1:31:23] — The emotional weight of prostate cancer uncertainty
[1:41:23] — Why you can’t biohack your way out of medical care
 
 
































 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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