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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
The Powerful Effect of Estrogen
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<blockquote data-quote="Nelson Vergel" data-source="post: 76416" data-attributes="member: 3"><p>Good article but he fails to say what "low" or "high" estradiol is. He also fails to mention that "high estradiol symptoms" should not be assumed without an actual sensitive estradiol blood test since water retention, nipple sensitivity, and "moodiness" may have nothing to do with high estradiol. In fact, many men have these symptoms with sensitive estradiol under 40 pg/mL. Decreased cortisol clearance could be implicated in water retention.</p><p></p><p>There is not one study that has used the sensitive estradiol test to determine what is "high" estradiol while they control for testosterone blood levels and comorbidities. Is a estradiol of 45 pg/ml considered high for a man with testosterone of 1000 ng/dL? How about for a man with 350 ng/dL? Not one study has been done to prove that "high estradiol symptoms" improve with anastrozole. Not one! But doctors use anastrozole following dogma and because of pressure from misinformed patients.</p><p></p><p>In healthy men, 0.3% of testosterone is aromatized to estradiol in the testicles, liver and fat mass. The higher the T, the higher the E2. Assuming that there is a "high" estradiol level for all men regardless of T level is wrong. This downstream hormone balances and enhances the effect of testosterone specially in lipid control, cognitive function, libido, body composition and bone density. Too many factors to consider before abusing anastrozole!</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 76416, member: 3"] Good article but he fails to say what "low" or "high" estradiol is. He also fails to mention that "high estradiol symptoms" should not be assumed without an actual sensitive estradiol blood test since water retention, nipple sensitivity, and "moodiness" may have nothing to do with high estradiol. In fact, many men have these symptoms with sensitive estradiol under 40 pg/mL. Decreased cortisol clearance could be implicated in water retention. There is not one study that has used the sensitive estradiol test to determine what is "high" estradiol while they control for testosterone blood levels and comorbidities. Is a estradiol of 45 pg/ml considered high for a man with testosterone of 1000 ng/dL? How about for a man with 350 ng/dL? Not one study has been done to prove that "high estradiol symptoms" improve with anastrozole. Not one! But doctors use anastrozole following dogma and because of pressure from misinformed patients. In healthy men, 0.3% of testosterone is aromatized to estradiol in the testicles, liver and fat mass. The higher the T, the higher the E2. Assuming that there is a "high" estradiol level for all men regardless of T level is wrong. This downstream hormone balances and enhances the effect of testosterone specially in lipid control, cognitive function, libido, body composition and bone density. Too many factors to consider before abusing anastrozole! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
The Powerful Effect of Estrogen
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