The Powerful Effect of Estrogen

[Gene Devine]

The following paper was written by my good friend Dr. John Crisler focusing on estrogen, estrogen management, testosterone injection protocols and hormonal balance in men. I highly suggest all members, regardless of your knowledge, to follow and read his work...it's excellent and on point.

The powerful effect of estrogen

 

[lowe2sucks]

he stated the symptoms which happen with both low and high e2 but said it's elevated estrogen. it will get people confused.

 

[Nelson Vergel]

Good article but he fails to say what "low" or "high" estradiol is. He also fails to mention that "high estradiol symptoms" should not be assumed without an actual sensitive estradiol blood test since water retention, nipple sensitivity, and "moodiness" may have nothing to do with high estradiol. In fact, many men have these symptoms with sensitive estradiol under 40 pg/mL. Decreased cortisol clearance could be implicated in water retention.

There is not one study that has used the sensitive estradiol test to determine what is "high" estradiol while they control for testosterone blood levels and comorbidities. Is a estradiol of 45 pg/ml considered high for a man with testosterone of 1000 ng/dL? How about for a man with 350 ng/dL? Not one study has been done to prove that "high estradiol symptoms" improve with anastrozole. Not one! But doctors use anastrozole following dogma and because of pressure from misinformed patients.

In healthy men, 0.3% of testosterone is aromatized to estradiol in the testicles, liver and fat mass. The higher the T, the higher the E2. Assuming that there is a "high" estradiol level for all men regardless of T level is wrong. This downstream hormone balances and enhances the effect of testosterone specially in lipid control, cognitive function, libido, body composition and bone density. Too many factors to consider before abusing anastrozole!

 

[Gene Devine]

Good article but he fails to say what "low" or "high" estradiol is. He also fails to mention that "high estradiol symptoms" should not be assumed without an actual sensitive estradiol blood test since water retention, nipple sensitivity, and "moodiness" may have nothing to do with high estradiol. In fact, many men have these symptoms with sensitive estradiol under 40 pg/mL. Decreased cortisol clearance could be implicated in water retention.

There is not one study that has used the sensitive estradiol test to determine what is "high" estradiol while they control for testosterone blood levels and comorbidities. Is a estradiol of 45 pg/ml considered high for a man with testosterone of 1000 ng/dL? How about for a man with 350 ng/dL? Not one study has been done to prove that "high estradiol symptoms" improve with anastrozole. Not one! But doctors use anastrozole following dogma and because of pressure from misinformed patients.

In healthy men, 0.3% of testosterone is aromatized to estradiol in the testicles, liver and fat mass. The higher the T, the higher the E2. Assuming that there is a "high" estradiol level for all men regardless of T level is wrong. This downstream hormone balances and enhances the effect of testosterone specially in lipid control, cognitive function, libido, body composition and bone density. Too many factors to consider before abusing anastrozole!

I think he was clear that labs for elevated E2 are not as important as the symptomatic presence of such. He states that if a man has no symptoms whatsoever, and he states what they are, he doesn't treat. Labs only come into play if there are tell tale signs of elevated E2 then he treat s very carefully...that's what I got out of it; besides the fact that two many men are starting out with Testosterone doses far in excess then where they should (i.e. 100mg weekly).

 

[AbsoluteZ3R0]

he stated the symptoms which happen with both low and high e2 but said it's elevated estrogen. it will get people confused.

Water retention/bloat and nipple discomfort are not typically symptoms of low estrogen, but the others can be.

 

[tLearner]

the original link is now bad and should be removed
archived version

 

[Vince]

the original link is now bad and should be removed
archived version

Thanks, I updated it.

 

[captain]

He put me on anastrozole with E2 of 17 and no symptoms whatsoever. I asked what are we doing here E2 is not high and he said it will be. Well it wasn't and has never been high at any T dose. Treating carefully wasn't what I got from him but he may have believed in what he was doing.

 

[Vince]

He put me on anastrozole with E2 of 17 and no symptoms whatsoever. I asked what are we doing here E2 is not high and he said it will be. Well it wasn't and has never been high at any T dose. Treating carefully wasn't what I got from him but he may have believed in what he was doing.

If you're E2 is at 17, no need for an AI.