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“What [we] found was that those men who received a penile implant had a significant reduction in depression and psychological distress," says Mohit Khera, MD, MBA, MPH.
www.urologytimes.com
Implantable penile prosthesis treatment for erectile dysfunction was associated with improvements in depression and psychological distress, according to recent data presented at the 2025 American Urological Association (AUA) Annual Meeting in Las Vegas, Nevada.1
Lead author Mohit Khera, MD, MBA, MPH, recently sat down with Urology Times® to discuss these findings and their implication for clinical practice.
He explained, “What [we] found was that those men who received a penile implant had a significant reduction in depression and psychological distress. In fact, it was a 50% reduction in depression, [and] it was a 50% reduction in psychological distress. We did not see a significant reduction in anxiety, which we thought we would have. But again, depression and psychological distress were significantly improved in men who received a penile implant.”
Khera is a professor of urology at Baylor College of Medicine in Houston, Texas.
Specifically, data showed that the proporation of patients characterized as having moderate psychological distress symptoms decreased from 54.4% pre-implant to 27.8% post-implant (P < .0001) per the Patient Health Questionnaire (PHQ).
The authors also reported, “The mean scores improved by more than 50% post-implant for the PHQ-2 depression (P < .0001), and the PHQ-4 depression and anxiety questionnaires (P = .0117). Overall mean PHQ9 scores dropped post-implant by -4.6 (95% CI, -7.5 to -1.8; P = .0028) and -5.8 (95% CI, -10.1 to -1.5; P = .0222) points in those with mild and moderate pre-implant depression, respectively.”
According to Khera, mental health and erectile function have a bi-directional relationship, and urologists should consider mental health when they are caring for these patients.
He concluded, “We really need to screen for depression and anxiety when we see men who present with erectile dysfunction, because that may be the underlying cause.”
Mohit Khera, MD, on the impact of penile prosthesis implant on mental health
“What [we] found was that those men who received a penile implant had a significant reduction in depression and psychological distress," says Mohit Khera, MD, MBA, MPH.
Implantable penile prosthesis treatment for erectile dysfunction was associated with improvements in depression and psychological distress, according to recent data presented at the 2025 American Urological Association (AUA) Annual Meeting in Las Vegas, Nevada.1
Lead author Mohit Khera, MD, MBA, MPH, recently sat down with Urology Times® to discuss these findings and their implication for clinical practice.
He explained, “What [we] found was that those men who received a penile implant had a significant reduction in depression and psychological distress. In fact, it was a 50% reduction in depression, [and] it was a 50% reduction in psychological distress. We did not see a significant reduction in anxiety, which we thought we would have. But again, depression and psychological distress were significantly improved in men who received a penile implant.”
Khera is a professor of urology at Baylor College of Medicine in Houston, Texas.
Specifically, data showed that the proporation of patients characterized as having moderate psychological distress symptoms decreased from 54.4% pre-implant to 27.8% post-implant (P < .0001) per the Patient Health Questionnaire (PHQ).
The authors also reported, “The mean scores improved by more than 50% post-implant for the PHQ-2 depression (P < .0001), and the PHQ-4 depression and anxiety questionnaires (P = .0117). Overall mean PHQ9 scores dropped post-implant by -4.6 (95% CI, -7.5 to -1.8; P = .0028) and -5.8 (95% CI, -10.1 to -1.5; P = .0222) points in those with mild and moderate pre-implant depression, respectively.”
According to Khera, mental health and erectile function have a bi-directional relationship, and urologists should consider mental health when they are caring for these patients.
He concluded, “We really need to screen for depression and anxiety when we see men who present with erectile dysfunction, because that may be the underlying cause.”
