The Effect of Estrogen on Tendon and Ligament Metabolism and Function



Table of Contents


Another possible positive benefit for e2?

3416.attach
Highlights



  • The effect of estrogens on tendons and ligaments is poorly understood.

  • Research implies a positive effect of estrogens on tendon tissue biology and biomechanics.

  • However, results are in part conflicting, highlighting the need of for further in-depth research in the field.


Abstract


Tendons and ligaments are crucial structures inside the musculoskeletal system. Still many issues in the treatment of tendon diseases and injuries have yet not been resolved sufficiently. In particular, the role of estrogen-like compound (ELC) in tendon biology has received until now little attention in modern research, despite ELC being a well-studied and important factor in the physiology of other parts of the musculoskeletal system.
In this review we attempt to summarize the available information on this topic and to determine many open questions in this field.
http://www.sciencedirect.com/science/article/pii/S0960076017301590
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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