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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
The Dynamics of Allosteric Binding of Estradiol to SHBG
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<blockquote data-quote="madman" data-source="post: 199561" data-attributes="member: 13851"><p><strong>Figure 7. Estradiol binding to either of the two monomers alters the conformational energy landscape of the other monomer. The three panels collectively show the ensemble allosteric modulation of relative probabilities of a population of clusters and respective transition rates between the conformational substates in response to estradiol binding to monomers. Panel A: The two unliganded SHBG monomers populate distinct conformational states. Panel B: Upon estradiol binding to monomer 1, not only are the conformational states of monomer 1 impacted but monomer 2 also is allosterically affected. Panel C illustrates that estradiol binding to monomer 2 alters the conformational states of the already bound monomer 1 such that even in the fully bound state, the monomers within the SHBG dimer are not equivalent and exhibit conformational heterogeneity.</strong></p><p><strong>[ATTACH=full]13805[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 199561, member: 13851"] [B]Figure 7. Estradiol binding to either of the two monomers alters the conformational energy landscape of the other monomer. The three panels collectively show the ensemble allosteric modulation of relative probabilities of a population of clusters and respective transition rates between the conformational substates in response to estradiol binding to monomers. Panel A: The two unliganded SHBG monomers populate distinct conformational states. Panel B: Upon estradiol binding to monomer 1, not only are the conformational states of monomer 1 impacted but monomer 2 also is allosterically affected. Panel C illustrates that estradiol binding to monomer 2 alters the conformational states of the already bound monomer 1 such that even in the fully bound state, the monomers within the SHBG dimer are not equivalent and exhibit conformational heterogeneity. [ATTACH type="full"]13805[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
The Dynamics of Allosteric Binding of Estradiol to SHBG
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