The dire consequences of doping

madman

Super Moderator
Various cases in professional sports have brought the matter of doping—the use of performance-enhancing drugs—to the attention of the broad public. Here, we present a case of doping in a 21-year-old amateur bodybuilder. The man presented to our clinic feeling generally unwell. He was subfebrile and had massive, deep ulcerations, abscesses, and pustules located on his chest and upper back (figure). Persistent questioning revealed a history of continuous abuse of anabolic-androgenic steroids (testosterone enanthate 250 mg plus methandienone 30 mg twice weekly), which was consistent with the diagnosis of severe acne conglobata that was anabolic-androgenic steroid-induced. Additional investigations showed a substantial impairment in sperm concentration and reduced testicular volume. Skin lesions showed rapid improvement after discontinuation of anabolic-androgenic steroid abuse and with antiseptic and antibiotic therapy. However, the extensive scarring is likely to remain with the young man for the rest of his life.
 
Figure: Severe acne conglobata induced by anabolic-androgenic steroids The patient at the time of his ideal body image; the 21-year-old bodybuilder had a history of anabolic-androgenic steroid abuse (A). Severe acne conglobata (B); lesions include papules, pustules, abscesses, and deep ulcerations. Patient after 6 weeks of antiseptic-antibiotic therapy (C).
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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