The Big D Mistake (review)

Will Brink

Member
This is an interesting review on the need to reevaluate the recommend levels of D3 intake to reach optimal levels of 25OHD. What caught my attention in particular was the claim there exists a statistical error "...in the Estimation of the Recommended Dietary Allowance of Vitamin D"





According to the author:




"... a correct reanalysis of the data used by the Institute of Medicine, proved that 8895 IU/d are needed for 97.5% of individuals to achieve values ≥50 nmol/L. Heaney et al. [9] confirmed that finding, reporting that 6201 IU/d were needed to achieve the Endocrine Society’s recommendation of 75 nmol/L and 9122 IU/day to reach 100 nmol/L."




Full paper:




https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/
 
Most doctors think checking a Vit D level is a complete waste of money. As long as the level is above 25ng/ml, they're very happy.

A typical starting dose beginning with your 25-hydroxy vitamin D level, is 6000-8000 units per day in oil-based gelcap form (to ensure absorption). I would wait 3 months before obtaining a follow-up level to allow a "steady-state" to be achieved.
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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