Testosterone versus Clomiphene ( Clomid ) for Low Testosterone Symptoms

[Nelson Vergel]

Testosterone versus clomiphene citrate in managing symptoms of hypogonadism in men

by Lipshultz, Larry; Scovell, Jason; Dadhich, Pranav;
Indian Journal of Urology, 07/2017, Volume 33, Issue 3


Introduction: Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. Patients and Methods: 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. These men were also compared to eugonadal men who were not on CC or TST during the same period. Comparisons were made between baseline and posttreatment hormone levels and symptoms. Symptoms were evaluated using the androgen deficiency in aging male (ADAM) and quantitative ADAM (qADAM) questionnaires. Results: Serum total testosterone increased from pretreatment levels in all men (P < 0.05), regardless of therapy type (TST: 281-541 ng/dL, CC: 235.5-438 ng/dL). Men taking TST reported fewer ADAM symptoms after treatment (5-2, P < 0.05). Similarly, men taking CC reported fewer ADAM symptoms after treatment (3.5-1.5, P < 0.05). Conversely, eugonadal men had similar T levels (352 vs. 364 ng/dL) and hypogonadal symptoms (1.5 vs. 1.4) before and after follow-up. When we evaluated individual symptoms, men treated with TST showed significant increases in qADAM scores in libido, erectile function, and sports performance. However, among the men who received CC, qADAM subscore for libido was lower following treatment (3.75-3.2, P = 0.04), indicating that CC could have an adverse effect on libido in hypogonadal men. Conclusions: Both TST and CC are effective medications in treating hypogonadism; however, our study indicates that TST is more effective in raising serum testosterone levels and improving hypogonadal symptoms. CC remains a viable treatment modality for hypogonadal men but its adverse effect on libido warrant further study

 

[Sean Mosher]

Is this probably due to the effect that there tends to be a general higher increase in estrogen in men using CC for low T treatment?
And we could probably see why as there is much confusion out there when it comes to proper estrogen management with any form of TRT.

 

[Vince Carter]

and we know Clomiophene is typically overdosed @ 25 or even 50mg/D which in turn leads to the E problems.

 

[lowe2sucks]

https://www.excelmale.com/forum/sho...ssociated-Suicide-Behavior-in-Hypogonadal-Man
I ovulate on my own, my cycles are perfect, dye test perfect, all blood work was perfect but because of my age and length of ttc the Specialist recommended IUI and started me on 50mg of clomid, hcg trigger, and progesterone. Month one taking Clomid, my mood swings were horrible. I cried, got mad, yelled screamed, and extremely depressed. Month two- same thing but worse. Month three- depressed beyond belief and started having suicidal thoughts. I NEVER in my life have ever had any type of thoughts like this before. I went to seek treatment because it scared me.

I know I'm not crazy but I haven't found a lot of information about this as a side effect. PLEASE someone tell me they have felt this way. The symptoms start about 24-48 hours after first clomid pill and last about 5 days.
http://www.fertilethoughts.com/forums/intrauterine-insemination-iui-/716626-clomid-crazies-questions.html
https://www.excelmale.com/forum/showthread.php?8582-Feeling-bad-on-low-dose-Clomid-12-5-mg-day
raise your testosterone and want to suicide great idea I don't recall being suicidal an effect of high testosterone.... we can laugh here but really is this shit still being prescribed?? doctors should know about possible side effects of it.. AIs won't fix these side effects because they are not high e2 side effects