Testosterone vaginal cream versus estrogens for the treatment of vulvovaginal atrophy in postmenopausal women

madman

Super Moderator
Hormonal, metabolic, and endometrial safety of testosterone vaginal cream versus estrogens for the treatment of vulvovaginal atrophy in postmenopausal women: a randomized, placebo-controlled study
Tatiane Fernandes, MD, Adriana O. Pedro, MD, PhD, Luiz F. Baccaro, MD, PhD,
and Lucia H. Costa-Paiva, MD, PhD



CONCLUSIONS

In conclusion, these data show that 12 weeks of treatment with topical testosterone or topical estrogen in postmenopausal women with symptoms of vaginal atrophy demonstrated laboratory and endometrial safety when compared with placebo. The high prevalence of symptomatology in menopausal urogenital atrophy reinforces the need to explore alternative treatments to estrogen therapy to improve the quality of life of these women.
 

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This article was right on time.
My wife is five years Post menopausal and is just starting to suffer with Vaginal Atrophy with some pain.
Very frustrating as we've always had a very active sex life.
Has anyone been treated by Defy or maybe can give advice as to a way forward.
We do not want the status quo Hormone replacement that the ADA docs provide.
 

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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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