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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone/TRT and Sleep
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<blockquote data-quote="madman" data-source="post: 216879" data-attributes="member: 13851"><p>Would be something to look into down the road once he gets on a sensible trt protocol let alone give it enough time to see how his body reacts to testosterone and what impact it will have on blood markers such as RBCs/hemoglobin/hematocrit.</p><p></p><p>Even then although many may get relief/improvement of joint/bone pain when using therapeutic doses of 50-100mg ND/week it is not a given.</p><p></p><p>Let alone nandrolone is not healing/preventing any degeneration/damage of the joints/tendons/ligaments which many of the misinformed tend to claim.</p><p></p><p>It will enhance lubrication in the joints.</p><p></p><p>Its main advantage is its strong anabolic/anti-catabolic properties and is known to bind strongly to the AR (>testosterone).</p><p></p><p>ND is a potent available anabolic steroid with minimal androgenic side effects.</p><p></p><p>Keep in mind that there is no guarantee of a free lunch when using therapeutic doses of nandrolone long-term.</p><p></p><p></p><p><em><strong>*It is unclear to what extent, if any, these risks would apply to nandrolone administration at a more reasonable dosage in a clinical setting. <u>Thus far, the controlled clinical trials of nandrolone have been too small and too sparse to confidently assess the risks of physician-prescribed and monitored nandrolone treatment at appropriate dosing</u></strong></em></p><p></p><p></p><p></p><p></p><p><strong>Nandrolone decanoate relieves joint pain in hypogonadal men: a novel prospective pilot study and review of the literature (2019)</strong></p><p></p><p></p><p><em><strong>Historical clinical applications Nandrolone was initially FDA approved in 1962 for the treatment of anemia resulting from chronic kidney disease (CKD) (18-20). </strong>While quite capable in this regard with fewer androgenic side effects compared to testosterone (the previous standard of care), nandrolone’s use in the treatment of anemia was largely supplanted in the late 1980s with the introduction of recombinant human erythropoietin (EPO) (21). Interestingly, nandrolone is still occasionally used as an alternative for select patients who cannot tolerate EPO and for patients in resource-limited countries (21-23). <strong>Outside of its historical indication for anemia, nandrolone has also shown promise in the treatment of osteoporosis and the sarcopenic states commonly observed in advanced chronic obstructive pulmonary disease (COPD), and acquired immunodeficiency syndrome (AIDS), and end-stage renal disease (ESRD) (24-27). </strong>Unfortunately, nandrolone decanoate (ND) is no longer commercially available within the United States and, therefore, must be compounded.</em></p><p></p><p></p><p></p><p></p><p><strong>Side effects</strong></p><p></p><p><em><strong>Nandrolone has been shown to possess a generally favorable side effect profile compared to most other AAS.</strong> Although any androgenic stimulation of the hair follicle and sebaceous sweat glands may result in alopecia, hirsutism, and acne, nandrolone’s weak androgenic activity makes these side effects uncommon (28). As an injectable oil, nandrolone is not subject to first-pass hepatic metabolism and is not hepatotoxic. Interestingly, although not well-described in the literature, some users of nandrolone have complained of temporary ED that resolves with cessation of therapy (13). This anecdotal side effect appears to be highly dependent on nandrolone dosage and the use or absence of concomitant testosterone. Although further studies regarding this are needed, plausible mechanisms for this include the insufficient androgenic activity of nandrolone itself and negative-feedback induced suppression of the HPG axis resulting in both reduced testosterone and DHT, the latter of which crucial to nitric-oxide mediated erectile function (13,29). Interference with the HPG axis also poses a significant risk to fertility and may risk the possibility for hypogonadism with long-term use in men who are not already testosterone deficient (30).</em></p><p><em></em></p><p><em><strong>It is important to note that the majority of the literature, which describes the adverse effects of nandrolone, does so in the setting of illicit AAS abuse (11,31,32). This patient population is notorious for utilizing very high doses of AAS and is fraught with polypharmacy.</strong> Thus, the usefulness of extrapolating these studies’ findings to appropriate medical therapy with nandrolone is extremely limited (33).<strong> In human studies, illicit, long-term AAS abuse has been associated with cardiovascular complications, such as cardiomyopathy and coronary artery disease (34,35). </strong>In rat models using approximately 20× doses of nandrolone used clinically; cardiomyopathy has also been observed (36-38).<strong> <u>It is unclear to what extent, if any, these risks would apply to nandrolone administration at a more reasonable dosage in a clinical setting. Thus far, the controlled clinical trials of nandrolone have been too small and too sparse to confidently assess the risks of physician-prescribed and monitored nandrolone treatment at appropriate dosing</u>.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>Novel pilot study</strong></p><p></p><p><em><strong>*As evidenced above, there is very little concrete data referencing any effect nandrolone may have regarding the alleviation of joint pain. <u>However, nandrolone does have well-documented advantageous effects on bone and muscle along with quality trials showing its benefit in osteoporotic bone pain and historical documentation of its efficacy for patellofemoral pain syndrome</u>. <u>Therefore, it is reasonable to postulate that the anecdotal evidence ascribing non-inflammatory joint pain relief to nandrolone may be accurate</u>. </strong>Additionally, male hypogonadism is linked with comorbidities such as diabetes and obesity, which are often associated with significant and debilitating joint pain (69,70). In such patients, the addition of nandrolone to their testosterone replacement regimen would avoid the potential side effect of ED, as discussed earlier, resulting in a highly tolerable option for pain management, if efficacious.</em></p><p></p><p></p><p></p><p><strong>post #9</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/bpc-157-amazing-healing-results.23620/#post-203213[/URL]</p><p></p><p><strong>post #2</strong></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/tendonitis-and-trt.24425/#post-212359[/URL]</p></blockquote><p></p>
[QUOTE="madman, post: 216879, member: 13851"] Would be something to look into down the road once he gets on a sensible trt protocol let alone give it enough time to see how his body reacts to testosterone and what impact it will have on blood markers such as RBCs/hemoglobin/hematocrit. Even then although many may get relief/improvement of joint/bone pain when using therapeutic doses of 50-100mg ND/week it is not a given. Let alone nandrolone is not healing/preventing any degeneration/damage of the joints/tendons/ligaments which many of the misinformed tend to claim. It will enhance lubrication in the joints. Its main advantage is its strong anabolic/anti-catabolic properties and is known to bind strongly to the AR (>testosterone). ND is a potent available anabolic steroid with minimal androgenic side effects. Keep in mind that there is no guarantee of a free lunch when using therapeutic doses of nandrolone long-term. [I][B]*It is unclear to what extent, if any, these risks would apply to nandrolone administration at a more reasonable dosage in a clinical setting. [U]Thus far, the controlled clinical trials of nandrolone have been too small and too sparse to confidently assess the risks of physician-prescribed and monitored nandrolone treatment at appropriate dosing[/U][/B][/I] [B]Nandrolone decanoate relieves joint pain in hypogonadal men: a novel prospective pilot study and review of the literature (2019)[/B] [I][B]Historical clinical applications Nandrolone was initially FDA approved in 1962 for the treatment of anemia resulting from chronic kidney disease (CKD) (18-20). [/B]While quite capable in this regard with fewer androgenic side effects compared to testosterone (the previous standard of care), nandrolone’s use in the treatment of anemia was largely supplanted in the late 1980s with the introduction of recombinant human erythropoietin (EPO) (21). Interestingly, nandrolone is still occasionally used as an alternative for select patients who cannot tolerate EPO and for patients in resource-limited countries (21-23). [B]Outside of its historical indication for anemia, nandrolone has also shown promise in the treatment of osteoporosis and the sarcopenic states commonly observed in advanced chronic obstructive pulmonary disease (COPD), and acquired immunodeficiency syndrome (AIDS), and end-stage renal disease (ESRD) (24-27). [/B]Unfortunately, nandrolone decanoate (ND) is no longer commercially available within the United States and, therefore, must be compounded.[/I] [B]Side effects[/B] [I][B]Nandrolone has been shown to possess a generally favorable side effect profile compared to most other AAS.[/B] Although any androgenic stimulation of the hair follicle and sebaceous sweat glands may result in alopecia, hirsutism, and acne, nandrolone’s weak androgenic activity makes these side effects uncommon (28). As an injectable oil, nandrolone is not subject to first-pass hepatic metabolism and is not hepatotoxic. Interestingly, although not well-described in the literature, some users of nandrolone have complained of temporary ED that resolves with cessation of therapy (13). This anecdotal side effect appears to be highly dependent on nandrolone dosage and the use or absence of concomitant testosterone. Although further studies regarding this are needed, plausible mechanisms for this include the insufficient androgenic activity of nandrolone itself and negative-feedback induced suppression of the HPG axis resulting in both reduced testosterone and DHT, the latter of which crucial to nitric-oxide mediated erectile function (13,29). Interference with the HPG axis also poses a significant risk to fertility and may risk the possibility for hypogonadism with long-term use in men who are not already testosterone deficient (30). [B]It is important to note that the majority of the literature, which describes the adverse effects of nandrolone, does so in the setting of illicit AAS abuse (11,31,32). This patient population is notorious for utilizing very high doses of AAS and is fraught with polypharmacy.[/B] Thus, the usefulness of extrapolating these studies’ findings to appropriate medical therapy with nandrolone is extremely limited (33).[B] In human studies, illicit, long-term AAS abuse has been associated with cardiovascular complications, such as cardiomyopathy and coronary artery disease (34,35). [/B]In rat models using approximately 20× doses of nandrolone used clinically; cardiomyopathy has also been observed (36-38).[B] [U]It is unclear to what extent, if any, these risks would apply to nandrolone administration at a more reasonable dosage in a clinical setting. Thus far, the controlled clinical trials of nandrolone have been too small and too sparse to confidently assess the risks of physician-prescribed and monitored nandrolone treatment at appropriate dosing[/U].[/B][/I] [B]Novel pilot study[/B] [I][B]*As evidenced above, there is very little concrete data referencing any effect nandrolone may have regarding the alleviation of joint pain. [U]However, nandrolone does have well-documented advantageous effects on bone and muscle along with quality trials showing its benefit in osteoporotic bone pain and historical documentation of its efficacy for patellofemoral pain syndrome[/U]. [U]Therefore, it is reasonable to postulate that the anecdotal evidence ascribing non-inflammatory joint pain relief to nandrolone may be accurate[/U]. [/B]Additionally, male hypogonadism is linked with comorbidities such as diabetes and obesity, which are often associated with significant and debilitating joint pain (69,70). In such patients, the addition of nandrolone to their testosterone replacement regimen would avoid the potential side effect of ED, as discussed earlier, resulting in a highly tolerable option for pain management, if efficacious.[/I] [B]post #9[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/bpc-157-amazing-healing-results.23620/#post-203213[/URL] [B]post #2[/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/tendonitis-and-trt.24425/#post-212359[/URL] [/QUOTE]
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