Testosterone Therapy and Liver Fat

[Excel Male]

Testosterone administration in older men with mobility limitation and low testosterone levels was not associated with a reduction in hepatic fat.

Effect of Testosterone Administration on Liver Fat in Older Men With Mobility Limitation: Results From a Randomized Controlled Trial

More on fatty liver and its consequences:

Nonalcoholic fatty liver disease is now the most common cause of chronic liver disease in the U.S. Some people with excess fat in the liver simply have what's called a fatty liver. Although this is not normal, it is not serious if it doesn't lead to inflammation or damage.
Others have what's called nonalcoholic steatohepatisis (NASH). Although it is similar to alcoholic liver disease, people with this type of fatty liver disease drink little or no alcohol. NASH can lead to permanent liver damage. The liver may enlarge and, over time, liver cells may be replaced by scar tissue. This is called cirrhosis. The liver can't work right and you may develop liver failure, liver cancer, and liver-related death. NASH is one of the leading causes of cirrhosis.

Both types of NAFLD are becoming more common. Up to 20% of adults may have either fatty liver or NASH. And more than 6 million children have one of these conditions, which are most common in Asian and Hispanic children. Recent evidence indicates that NAFLD increases the risk of heart disease in children who are overweight or obese.


Source: http://www.webmd.com/hepatitis/fatty-liver-disease

 

[Nelson Vergel]

J Clin Endocrinol Metab. 2019 Aug 1. pii: jc.2019-00160. doi: 10.1210/jc.2019-00160.

Overeating saturated fat promotes fatty liver and ceramides compared to polyunsaturated fat: a randomized trial.


CONTEXT:
Saturated fat (SFA) versus polyunsaturated fat (PUFA) may promote non-alcoholic fatty liver disease (NAFLD) by yet unclear mechanisms.

OBJECTIVE:
To investigate if overeating SFA- and PUFA-enriched diets lead to differential liver fat accumulation in overweight and obese humans.

DESIGN:
Double-blind randomized trial (LIPOGAIN-2). Overfeeding SFA vs PUFA for 8 weeks, followed by 4 weeks of caloric restriction.

SETTING:
General community.Participants: n=61 overweight or obese men and women.

INTERVENTION:
Muffins high in either palm (SFA)- or sunflower oil (PUFA) were added to the habitual diet.

MAIN OUTCOME MEASURE:
Lean tissue mass (not reported here). Secondary and exploratory outcomes included liver and ectopic fat depots.

RESULTS:
By design, body weight gain was similar in SFA (2.31±1.38 kg) and PUFA (2.01±1.90 kg) groups, P=0.50. SFA markedly induced liver fat content (50% relative increase) along with liver enzymes and atherogenic serum lipids. In contrast, despite similar weight gain, PUFA did not increase liver fat or liver enzymes or cause any adverse effects on blood lipids. SFA had no differential effect on the accumulation of visceral fat, pancreas fat or total body fat compared with PUFA. SFA consistently increased, while PUFA reduced circulating ceramides; changes that were moderately associated with liver fat changes and proposed markers of hepatic lipogenesis. The adverse metabolic effects of SFA were reversed by calorie restriction.

CONCLUSIONS:
Saturated fat markedly induces liver fat and serum ceramides whereas dietary polyunsaturated fat prevent liver fat accumulation, reduce ceramides and hyperlipidemia during excess energy intake and weight gain in overweight individuals.

 

[Nelson Vergel]

 

[Nelson Vergel]

Low SHBG is Correlated to Fatty Liver

 

[Nelson Vergel]

What is NAFLD/NASH?

www.excelmale.com

 

[Nelson Vergel]

Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations - PubMed

Testosterone therapy was associated with a reduction in hepatic steatosis in men with diabetes and low serum testosterone. Future randomised studies of testosterone therapy in men with NAFLD focusing on liver-related endpoints are therefore justified.

pubmed.ncbi.nlm.nih.gov

 

[Nelson Vergel]

Long-term treatment with testosterone undecanoate injection improves fatty liver and kidney function in men with hypogonadism

Hypogonadism is receiving recognition for being a risk factor for fatty liver and impaired kidney function. Emerging data, summarized here, suggest that long-term treatment with testosterone undecanoate injection may improve both liver and kidney function.

www.nebido.com

 

[madman]

LONG-TERM TESTOSTERONE THERAPY IMPROVES RENAL FUNCTION IN MEN WITH FUNCTIONAL HYPOGONADISM

LONG-TERM TESTOSTERONE THERAPY IMPROVES RENAL FUNCTION IN MEN WITH FUNCTIONAL HYPOGONADISM: EXPERIENCE FROM AN OBSERVATIONAL REGISTRY STUDY (2022) Karim Sultan Haider, Ahmad Haider, Gheorghe Doros, Farid Saad, Abdulmaged Traish Private Urology Practice, Bremerhaven, Germany; Department of...

www.excelmale.com

 

[DixieWrecked]

Udca or tudca or bile salts should help to protect the liver.