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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone Propionate Side Effects
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<blockquote data-quote="Cataceous" data-source="post: 184417" data-attributes="member: 38109"><p>It depends on how you interpret these things. In general, <em>average</em> levels of all the hormones—as measured by areas under the curves—are going to be directly proportional to the testosterone dose, which can be independent of the ester you use if you account for the ester's weight. For example, injecting 100 mg of testosterone cypionate once a week would be matched by taking 12 mg of testosterone propionate daily; both give about 70 mg of testosterone per week. <em>Average</em> serum testosterone, estradiol and DHT should be the same.</p><p></p><p>However, the pharmacokinetics of different esters can be quite different. Cypionate has a half-life of 5 days, whereas propionate's is more like 0.8 days. Using the same injection cycle, the shorter ester gives higher peaks and lower troughs in the serum hormone levels, and could be said to be "spiking" hormones more than the longer ester, even though average levels are the same.</p><p></p><p>I had a pretty dramatic illustration of these differences when last year I switched from EOD enanthate to daily propionate. On enanthate serum testosterone was pretty steady at just under 800 ng/dL. On propionate with about the same average testosterone content I was seeing trough measurements around 300-500 ng/dL. I was also experiencing pretty dramatic hair shedding. I eventually realized that my daily peak testosterone was peaking at well over 1,000 ng/dL, presumably with similar effects on estradiol and DHT. I made adjustments to push peak testosterone down to 800 ng/dL and the problems stopped.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 184417, member: 38109"] It depends on how you interpret these things. In general, [I]average[/I] levels of all the hormones—as measured by areas under the curves—are going to be directly proportional to the testosterone dose, which can be independent of the ester you use if you account for the ester's weight. For example, injecting 100 mg of testosterone cypionate once a week would be matched by taking 12 mg of testosterone propionate daily; both give about 70 mg of testosterone per week. [I]Average[/I] serum testosterone, estradiol and DHT should be the same. However, the pharmacokinetics of different esters can be quite different. Cypionate has a half-life of 5 days, whereas propionate's is more like 0.8 days. Using the same injection cycle, the shorter ester gives higher peaks and lower troughs in the serum hormone levels, and could be said to be "spiking" hormones more than the longer ester, even though average levels are the same. I had a pretty dramatic illustration of these differences when last year I switched from EOD enanthate to daily propionate. On enanthate serum testosterone was pretty steady at just under 800 ng/dL. On propionate with about the same average testosterone content I was seeing trough measurements around 300-500 ng/dL. I was also experiencing pretty dramatic hair shedding. I eventually realized that my daily peak testosterone was peaking at well over 1,000 ng/dL, presumably with similar effects on estradiol and DHT. I made adjustments to push peak testosterone down to 800 ng/dL and the problems stopped. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone Propionate Side Effects
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