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The problem is that if SHBG doesn't affect the apparent ester half-life then serum testosterone in response to an injection should look the same for any SHBG, except for a multiplicative factor. So in theory the low-SHBG guy could simply adjust the dose to match serum testosterone of the high-SHBG guy. The need to match free testosterone would explain the benefits of smaller doses for low-SHBG guys. But it doesn't explain why more frequent injections are helpful.


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