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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Testosterone plus Clomid Combination
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<blockquote data-quote="Cataceous" data-source="post: 203448" data-attributes="member: 38109"><p>As long as we're keeping this thread alive... I think this explanation needs to be improved. It seems likely that exogenous testosterone can be more suppressive than endogenous. It was pointed out that some men can attain high serum testosterone with only Clomid, e.g. 900 ng/dL. But with TRT, if you get anywhere near this serum level you will likely have quite low levels of LH and FSH, even with Clomid use. </p><p></p><p>A possible reason that's omitted is that androgens also cause negative feedback at the hypothalamus. So while Clomid and enclomiphene block negative feedback from estrogens at both the pituitary and hypothalamus, they do not stop the suppressive behavior of testosterone. We're still left with the question: Why is exogenous testosterone—with conventional delivery—more suppressive than endogenous testosterone? We might speculate that the pulsatile delivery of LH—and testosterone—has something to do with it. In support of this hypothesis: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423704/" target="_blank">endogenous testosterone is pulsed</a>; <a href="https://pubmed.ncbi.nlm.nih.gov/8504744/" target="_blank">constant testosterone is more suppressive than pulsed</a>; <a href="https://www.excelmale.com/forum/threads/acerus-pharmaceuticals-natesto%AE.23251/" target="_blank">Natesto's</a> pulsatile nature allows continued HPTA function even with relatively high peaks in serum testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 203448, member: 38109"] As long as we're keeping this thread alive... I think this explanation needs to be improved. It seems likely that exogenous testosterone can be more suppressive than endogenous. It was pointed out that some men can attain high serum testosterone with only Clomid, e.g. 900 ng/dL. But with TRT, if you get anywhere near this serum level you will likely have quite low levels of LH and FSH, even with Clomid use. A possible reason that's omitted is that androgens also cause negative feedback at the hypothalamus. So while Clomid and enclomiphene block negative feedback from estrogens at both the pituitary and hypothalamus, they do not stop the suppressive behavior of testosterone. We're still left with the question: Why is exogenous testosterone—with conventional delivery—more suppressive than endogenous testosterone? We might speculate that the pulsatile delivery of LH—and testosterone—has something to do with it. In support of this hypothesis: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC423704/']endogenous testosterone is pulsed[/URL]; [URL='https://pubmed.ncbi.nlm.nih.gov/8504744/']constant testosterone is more suppressive than pulsed[/URL]; [URL='https://www.excelmale.com/forum/threads/acerus-pharmaceuticals-natesto%AE.23251/']Natesto's[/URL] pulsatile nature allows continued HPTA function even with relatively high peaks in serum testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Testosterone plus Clomid Combination
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