Testosterone Oils: Cottonseed vs Sesame Seed Oils

Hi Vince. My name is Jasen and I have worked in a compounding pharmacy and have worked with compounders for roughly 8 years. Most manufactured testosterone injectables are suspended in cottonseed or sometimes sesame seed oil. Both of these oils are sterilized and pass USP standards, but they are indeed "cheaper" oils typically used in mass-produced testosterone. Compounding pharmacies can use any oil you and your physician requests, like grapeseed and sesame oils. The amount of the oil injected should not be a concern as it is such as small amount, which the body will metabolize, and it is sterilized of impurities. Unless you are allergic to the oil itself than I would not be concerned at all. If you are allergic to cottonseed than you will want to choose another oil to avoid a reaction.

Although you did not ask about the difference between testosterone enanthate and cypionate, here is a link which discusses the different testosterone esters: http://defymedical.com/resources/health-articles/187-common-injectable-testosterone-esters
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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